Improved percutaneous delivery of some NSAIDs for the treatment of arthritis

Arthritis is a heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage. Major classes of drugs which are widely used for the treatment of arthritis are Non-Steroidal Anti-inflammatory Drugs (NSAIDs). Development of...

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Detalles Bibliográficos
Autores principales: Thosani, Rushabh, Pawar, Vijay, Giridhar, Rajani, Yadav, Mange Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467824/
https://www.ncbi.nlm.nih.gov/pubmed/23066187
http://dx.doi.org/10.4103/0975-7406.94120
Descripción
Sumario:Arthritis is a heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage. Major classes of drugs which are widely used for the treatment of arthritis are Non-Steroidal Anti-inflammatory Drugs (NSAIDs). Development of an efficient means of percutaneous delivery can increase drug concentration in local soft-tissues and joints while reducing the systemic distribution of a drug and its side effects. The present work is aimed at synthesisand evaluation of prodrugs of some NSAIDs for percutaneous drug delivery for the treatment of arthritis.

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