Improved percutaneous delivery of some NSAIDs for the treatment of arthritis

Arthritis is a heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage. Major classes of drugs which are widely used for the treatment of arthritis are Non-Steroidal Anti-inflammatory Drugs (NSAIDs). Development of...

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Autores principales: Thosani, Rushabh, Pawar, Vijay, Giridhar, Rajani, Yadav, Mange Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467824/
https://www.ncbi.nlm.nih.gov/pubmed/23066187
http://dx.doi.org/10.4103/0975-7406.94120
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author Thosani, Rushabh
Pawar, Vijay
Giridhar, Rajani
Yadav, Mange Ram
author_facet Thosani, Rushabh
Pawar, Vijay
Giridhar, Rajani
Yadav, Mange Ram
author_sort Thosani, Rushabh
collection PubMed
description Arthritis is a heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage. Major classes of drugs which are widely used for the treatment of arthritis are Non-Steroidal Anti-inflammatory Drugs (NSAIDs). Development of an efficient means of percutaneous delivery can increase drug concentration in local soft-tissues and joints while reducing the systemic distribution of a drug and its side effects. The present work is aimed at synthesisand evaluation of prodrugs of some NSAIDs for percutaneous drug delivery for the treatment of arthritis.
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spelling pubmed-34678242012-10-12 Improved percutaneous delivery of some NSAIDs for the treatment of arthritis Thosani, Rushabh Pawar, Vijay Giridhar, Rajani Yadav, Mange Ram J Pharm Bioallied Sci Original/Brief Arthritis is a heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage. Major classes of drugs which are widely used for the treatment of arthritis are Non-Steroidal Anti-inflammatory Drugs (NSAIDs). Development of an efficient means of percutaneous delivery can increase drug concentration in local soft-tissues and joints while reducing the systemic distribution of a drug and its side effects. The present work is aimed at synthesisand evaluation of prodrugs of some NSAIDs for percutaneous drug delivery for the treatment of arthritis. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3467824/ /pubmed/23066187 http://dx.doi.org/10.4103/0975-7406.94120 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original/Brief
Thosani, Rushabh
Pawar, Vijay
Giridhar, Rajani
Yadav, Mange Ram
Improved percutaneous delivery of some NSAIDs for the treatment of arthritis
title Improved percutaneous delivery of some NSAIDs for the treatment of arthritis
title_full Improved percutaneous delivery of some NSAIDs for the treatment of arthritis
title_fullStr Improved percutaneous delivery of some NSAIDs for the treatment of arthritis
title_full_unstemmed Improved percutaneous delivery of some NSAIDs for the treatment of arthritis
title_short Improved percutaneous delivery of some NSAIDs for the treatment of arthritis
title_sort improved percutaneous delivery of some nsaids for the treatment of arthritis
topic Original/Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467824/
https://www.ncbi.nlm.nih.gov/pubmed/23066187
http://dx.doi.org/10.4103/0975-7406.94120
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AT giridharrajani improvedpercutaneousdeliveryofsomensaidsforthetreatmentofarthritis
AT yadavmangeram improvedpercutaneousdeliveryofsomensaidsforthetreatmentofarthritis

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