Formulation development and optimization of polyox based quick dissolving film of quetiapine

Quick dissolving film prepared by various grades of polyox like Polyox N10, N80, N750 and N205. Polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. Film is optimized for concentration of polymer and plasticize...

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Detalles Bibliográficos
Autores principales: Chaudhary, A. Sunita, Chaudhary, B. Ankit, Mehta, A. Tejal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467829/
https://www.ncbi.nlm.nih.gov/pubmed/23066190
http://dx.doi.org/10.4103/0975-7406.94123
Descripción
Sumario:Quick dissolving film prepared by various grades of polyox like Polyox N10, N80, N750 and N205. Polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. Film is optimized for concentration of polymer and plasticizer using CCD design. The tensile Strength, folding Endurance, % drug released at 10 min (Y10) and disintegration time were selected as dependent variables. The data revealed that 2% of polyox N 750 and 15% of PEG 400 showed excellent film forming property with rapid drug release profile.

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