Formulation development and optimization of polyox based quick dissolving film of quetiapine

Quick dissolving film prepared by various grades of polyox like Polyox N10, N80, N750 and N205. Polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. Film is optimized for concentration of polymer and plasticize...

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Detalles Bibliográficos
Autores principales: Chaudhary, A. Sunita, Chaudhary, B. Ankit, Mehta, A. Tejal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467829/
https://www.ncbi.nlm.nih.gov/pubmed/23066190
http://dx.doi.org/10.4103/0975-7406.94123
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author Chaudhary, A. Sunita
Chaudhary, B. Ankit
Mehta, A. Tejal
author_facet Chaudhary, A. Sunita
Chaudhary, B. Ankit
Mehta, A. Tejal
author_sort Chaudhary, A. Sunita
collection PubMed
description Quick dissolving film prepared by various grades of polyox like Polyox N10, N80, N750 and N205. Polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. Film is optimized for concentration of polymer and plasticizer using CCD design. The tensile Strength, folding Endurance, % drug released at 10 min (Y10) and disintegration time were selected as dependent variables. The data revealed that 2% of polyox N 750 and 15% of PEG 400 showed excellent film forming property with rapid drug release profile.
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spelling pubmed-34678292012-10-12 Formulation development and optimization of polyox based quick dissolving film of quetiapine Chaudhary, A. Sunita Chaudhary, B. Ankit Mehta, A. Tejal J Pharm Bioallied Sci Original/Brief Quick dissolving film prepared by various grades of polyox like Polyox N10, N80, N750 and N205. Polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. Film is optimized for concentration of polymer and plasticizer using CCD design. The tensile Strength, folding Endurance, % drug released at 10 min (Y10) and disintegration time were selected as dependent variables. The data revealed that 2% of polyox N 750 and 15% of PEG 400 showed excellent film forming property with rapid drug release profile. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3467829/ /pubmed/23066190 http://dx.doi.org/10.4103/0975-7406.94123 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original/Brief
Chaudhary, A. Sunita
Chaudhary, B. Ankit
Mehta, A. Tejal
Formulation development and optimization of polyox based quick dissolving film of quetiapine
title Formulation development and optimization of polyox based quick dissolving film of quetiapine
title_full Formulation development and optimization of polyox based quick dissolving film of quetiapine
title_fullStr Formulation development and optimization of polyox based quick dissolving film of quetiapine
title_full_unstemmed Formulation development and optimization of polyox based quick dissolving film of quetiapine
title_short Formulation development and optimization of polyox based quick dissolving film of quetiapine
title_sort formulation development and optimization of polyox based quick dissolving film of quetiapine
topic Original/Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467829/
https://www.ncbi.nlm.nih.gov/pubmed/23066190
http://dx.doi.org/10.4103/0975-7406.94123
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