Development of siRNA lipoplexes for intracellular delivery in lung cancer cells

Lung cancer occurrence throughout the world and its unsatisfactory treatment has drawn significant attention from many medical agencies. A genomic approach utilizing siRNA against target gene may resolve this problem. Present investigation includes siRNA lipoplex formulation and its in-vitro charact...

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Detalles Bibliográficos
Autores principales: Khatri, N., Misra, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467833/
https://www.ncbi.nlm.nih.gov/pubmed/23066176
http://dx.doi.org/10.4103/0975-7406.94115
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author Khatri, N.
Misra, A.
author_facet Khatri, N.
Misra, A.
author_sort Khatri, N.
collection PubMed
description Lung cancer occurrence throughout the world and its unsatisfactory treatment has drawn significant attention from many medical agencies. A genomic approach utilizing siRNA against target gene may resolve this problem. Present investigation includes siRNA lipoplex formulation and its in-vitro characterisation in lung cancer cell line for intracellular uptake and cytotoxicity. Accumulation of siRNA inside the cell as well as less cytotoxicity of prepared carrier system signifies potential of prepared siRNA lipoplex in the treatment of lung cancer.
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spelling pubmed-34678332012-10-12 Development of siRNA lipoplexes for intracellular delivery in lung cancer cells Khatri, N. Misra, A. J Pharm Bioallied Sci Original/Brief Lung cancer occurrence throughout the world and its unsatisfactory treatment has drawn significant attention from many medical agencies. A genomic approach utilizing siRNA against target gene may resolve this problem. Present investigation includes siRNA lipoplex formulation and its in-vitro characterisation in lung cancer cell line for intracellular uptake and cytotoxicity. Accumulation of siRNA inside the cell as well as less cytotoxicity of prepared carrier system signifies potential of prepared siRNA lipoplex in the treatment of lung cancer. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3467833/ /pubmed/23066176 http://dx.doi.org/10.4103/0975-7406.94115 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original/Brief
Khatri, N.
Misra, A.
Development of siRNA lipoplexes for intracellular delivery in lung cancer cells
title Development of siRNA lipoplexes for intracellular delivery in lung cancer cells
title_full Development of siRNA lipoplexes for intracellular delivery in lung cancer cells
title_fullStr Development of siRNA lipoplexes for intracellular delivery in lung cancer cells
title_full_unstemmed Development of siRNA lipoplexes for intracellular delivery in lung cancer cells
title_short Development of siRNA lipoplexes for intracellular delivery in lung cancer cells
title_sort development of sirna lipoplexes for intracellular delivery in lung cancer cells
topic Original/Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467833/
https://www.ncbi.nlm.nih.gov/pubmed/23066176
http://dx.doi.org/10.4103/0975-7406.94115
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