Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis

NSAIDs are among the most widely used prescription drugs, for the treatment of pain and inflammation, particularly arthritis. Inhibitor of COX and NSAIDs relieve the signs and symptoms of inflammation by decreasing PG production but may cause GI and renal damage. Synthesis, stability studies and Y-i...

Descripción completa

Detalles Bibliográficos
Autores principales: Pawar, Vijay, Gohil, Virpal, Tamboli, Riyaj, Giridhar, Rajani, Yadav, Mange Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467844/
https://www.ncbi.nlm.nih.gov/pubmed/23066177
http://dx.doi.org/10.4103/0975-7406.94119
Descripción
Sumario:NSAIDs are among the most widely used prescription drugs, for the treatment of pain and inflammation, particularly arthritis. Inhibitor of COX and NSAIDs relieve the signs and symptoms of inflammation by decreasing PG production but may cause GI and renal damage. Synthesis, stability studies and Y-imaging studies are carried out. Cartilage targeting strategy for conventional NSAIDs has been explored for reducing their local and systemic side effect of the NSAIDs site specific delivery of quarternary ester derivatives could have to be an effective strategy for long term therapy of inflammatory conditions like arthritis.

Ejemplares similares