Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis

NSAIDs are among the most widely used prescription drugs, for the treatment of pain and inflammation, particularly arthritis. Inhibitor of COX and NSAIDs relieve the signs and symptoms of inflammation by decreasing PG production but may cause GI and renal damage. Synthesis, stability studies and Y-i...

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Autores principales: Pawar, Vijay, Gohil, Virpal, Tamboli, Riyaj, Giridhar, Rajani, Yadav, Mange Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467844/
https://www.ncbi.nlm.nih.gov/pubmed/23066177
http://dx.doi.org/10.4103/0975-7406.94119
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author Pawar, Vijay
Gohil, Virpal
Tamboli, Riyaj
Giridhar, Rajani
Yadav, Mange Ram
author_facet Pawar, Vijay
Gohil, Virpal
Tamboli, Riyaj
Giridhar, Rajani
Yadav, Mange Ram
author_sort Pawar, Vijay
collection PubMed
description NSAIDs are among the most widely used prescription drugs, for the treatment of pain and inflammation, particularly arthritis. Inhibitor of COX and NSAIDs relieve the signs and symptoms of inflammation by decreasing PG production but may cause GI and renal damage. Synthesis, stability studies and Y-imaging studies are carried out. Cartilage targeting strategy for conventional NSAIDs has been explored for reducing their local and systemic side effect of the NSAIDs site specific delivery of quarternary ester derivatives could have to be an effective strategy for long term therapy of inflammatory conditions like arthritis.
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spelling pubmed-34678442012-10-12 Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis Pawar, Vijay Gohil, Virpal Tamboli, Riyaj Giridhar, Rajani Yadav, Mange Ram J Pharm Bioallied Sci Original/Brief NSAIDs are among the most widely used prescription drugs, for the treatment of pain and inflammation, particularly arthritis. Inhibitor of COX and NSAIDs relieve the signs and symptoms of inflammation by decreasing PG production but may cause GI and renal damage. Synthesis, stability studies and Y-imaging studies are carried out. Cartilage targeting strategy for conventional NSAIDs has been explored for reducing their local and systemic side effect of the NSAIDs site specific delivery of quarternary ester derivatives could have to be an effective strategy for long term therapy of inflammatory conditions like arthritis. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3467844/ /pubmed/23066177 http://dx.doi.org/10.4103/0975-7406.94119 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original/Brief
Pawar, Vijay
Gohil, Virpal
Tamboli, Riyaj
Giridhar, Rajani
Yadav, Mange Ram
Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis
title Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis
title_full Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis
title_fullStr Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis
title_full_unstemmed Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis
title_short Cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis
title_sort cartilage targeted chemical delivery of naproxen and ibuprofen for the treatment of arthritis
topic Original/Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467844/
https://www.ncbi.nlm.nih.gov/pubmed/23066177
http://dx.doi.org/10.4103/0975-7406.94119
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