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Host modulation by therapeutic agents
Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at br...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467936/ https://www.ncbi.nlm.nih.gov/pubmed/23066265 http://dx.doi.org/10.4103/0975-7406.100244 |
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author | Elavarasu, Sugumari Sekar, Santhosh Murugan, Thamaraiselvan |
author_facet | Elavarasu, Sugumari Sekar, Santhosh Murugan, Thamaraiselvan |
author_sort | Elavarasu, Sugumari |
collection | PubMed |
description | Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. Doxycycline, nonsteroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, nitrous oxide (NO) synthase inhibitors, recombinant human interleukin-11 (rhIL-11), omega-3 fatty acid, mouse anti-human interleukin-6 receptor antibody (MRA), mitogen-activated protein kinase (MAPK) inhibitors, nuclear factor-kappa B (NF-kb) inhibitors, osteoprotegerin, and tumor necrosis factor antagonist (TNF-α) are some of the therapeutic agents that have host modulation properties. |
format | Online Article Text |
id | pubmed-3467936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-34679362012-10-12 Host modulation by therapeutic agents Elavarasu, Sugumari Sekar, Santhosh Murugan, Thamaraiselvan J Pharm Bioallied Sci Dental Science - Review Article Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. Doxycycline, nonsteroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, nitrous oxide (NO) synthase inhibitors, recombinant human interleukin-11 (rhIL-11), omega-3 fatty acid, mouse anti-human interleukin-6 receptor antibody (MRA), mitogen-activated protein kinase (MAPK) inhibitors, nuclear factor-kappa B (NF-kb) inhibitors, osteoprotegerin, and tumor necrosis factor antagonist (TNF-α) are some of the therapeutic agents that have host modulation properties. Medknow Publications & Media Pvt Ltd 2012-08 /pmc/articles/PMC3467936/ /pubmed/23066265 http://dx.doi.org/10.4103/0975-7406.100244 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Dental Science - Review Article Elavarasu, Sugumari Sekar, Santhosh Murugan, Thamaraiselvan Host modulation by therapeutic agents |
title | Host modulation by therapeutic agents |
title_full | Host modulation by therapeutic agents |
title_fullStr | Host modulation by therapeutic agents |
title_full_unstemmed | Host modulation by therapeutic agents |
title_short | Host modulation by therapeutic agents |
title_sort | host modulation by therapeutic agents |
topic | Dental Science - Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467936/ https://www.ncbi.nlm.nih.gov/pubmed/23066265 http://dx.doi.org/10.4103/0975-7406.100244 |
work_keys_str_mv | AT elavarasusugumari hostmodulationbytherapeuticagents AT sekarsanthosh hostmodulationbytherapeuticagents AT muruganthamaraiselvan hostmodulationbytherapeuticagents |