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Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid
Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This paper summarizes the current literature regarding Banaba and its constituents. The hypoglycemic effects of Banaba have be...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468018/ https://www.ncbi.nlm.nih.gov/pubmed/23082086 http://dx.doi.org/10.1155/2012/871495 |
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author | Miura, Toshihiro Takagi, Satoshi Ishida, Torao |
author_facet | Miura, Toshihiro Takagi, Satoshi Ishida, Torao |
author_sort | Miura, Toshihiro |
collection | PubMed |
description | Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This paper summarizes the current literature regarding Banaba and its constituents. The hypoglycemic effects of Banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects, and in vitro systems using water soluble Banaba leaf extracts, corosolic acid, and ellagitannins. Corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic and antioxidant activities. The beneficial effects of Banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis, and the regulation of lipid metabolism. These effects may be mediated by PPAR and other signal transduction factors. Banaba extract, corosolic acid, and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits. |
format | Online Article Text |
id | pubmed-3468018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34680182012-10-18 Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid Miura, Toshihiro Takagi, Satoshi Ishida, Torao Evid Based Complement Alternat Med Review Article Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This paper summarizes the current literature regarding Banaba and its constituents. The hypoglycemic effects of Banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects, and in vitro systems using water soluble Banaba leaf extracts, corosolic acid, and ellagitannins. Corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic and antioxidant activities. The beneficial effects of Banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis, and the regulation of lipid metabolism. These effects may be mediated by PPAR and other signal transduction factors. Banaba extract, corosolic acid, and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3468018/ /pubmed/23082086 http://dx.doi.org/10.1155/2012/871495 Text en Copyright © 2012 Toshihiro Miura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Miura, Toshihiro Takagi, Satoshi Ishida, Torao Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid |
title | Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid |
title_full | Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid |
title_fullStr | Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid |
title_full_unstemmed | Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid |
title_short | Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid |
title_sort | management of diabetes and its complications with banaba (lagerstroemia speciosa l.) and corosolic acid |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468018/ https://www.ncbi.nlm.nih.gov/pubmed/23082086 http://dx.doi.org/10.1155/2012/871495 |
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