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HOX Gene Aberrant Expression in Skin Melanoma: A Review
The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis. A series of genes of the four HOX gene clusters A, B, C...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468127/ https://www.ncbi.nlm.nih.gov/pubmed/23091727 http://dx.doi.org/10.1155/2012/707260 |
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author | Piérard, Gérald E. Piérard-Franchimont, Claudine |
author_facet | Piérard, Gérald E. Piérard-Franchimont, Claudine |
author_sort | Piérard, Gérald E. |
collection | PubMed |
description | The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis. A series of genes of the four HOX gene clusters A, B, C, and D were reported to show aberrant expressions in oncogenesis, particularly in cutaneous malignant melanoma (CMM). They are involved in cell proliferation and progression in the CMM metastatic path. We present relevant peer-reviewed literature findings about the aberrant expression of HOX genes in CMM. The number of CMM cell nuclei exhibiting aberrant HOX protein expression appears correlated with tumour progression. |
format | Online Article Text |
id | pubmed-3468127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34681272012-10-22 HOX Gene Aberrant Expression in Skin Melanoma: A Review Piérard, Gérald E. Piérard-Franchimont, Claudine J Skin Cancer Review Article The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis. A series of genes of the four HOX gene clusters A, B, C, and D were reported to show aberrant expressions in oncogenesis, particularly in cutaneous malignant melanoma (CMM). They are involved in cell proliferation and progression in the CMM metastatic path. We present relevant peer-reviewed literature findings about the aberrant expression of HOX genes in CMM. The number of CMM cell nuclei exhibiting aberrant HOX protein expression appears correlated with tumour progression. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3468127/ /pubmed/23091727 http://dx.doi.org/10.1155/2012/707260 Text en Copyright © 2012 G. E. Piérard and C. Piérard-Franchimont. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Piérard, Gérald E. Piérard-Franchimont, Claudine HOX Gene Aberrant Expression in Skin Melanoma: A Review |
title | HOX Gene Aberrant Expression in Skin Melanoma: A Review |
title_full | HOX Gene Aberrant Expression in Skin Melanoma: A Review |
title_fullStr | HOX Gene Aberrant Expression in Skin Melanoma: A Review |
title_full_unstemmed | HOX Gene Aberrant Expression in Skin Melanoma: A Review |
title_short | HOX Gene Aberrant Expression in Skin Melanoma: A Review |
title_sort | hox gene aberrant expression in skin melanoma: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468127/ https://www.ncbi.nlm.nih.gov/pubmed/23091727 http://dx.doi.org/10.1155/2012/707260 |
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