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HOX Gene Aberrant Expression in Skin Melanoma: A Review

The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis. A series of genes of the four HOX gene clusters A, B, C...

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Detalles Bibliográficos
Autores principales: Piérard, Gérald E., Piérard-Franchimont, Claudine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468127/
https://www.ncbi.nlm.nih.gov/pubmed/23091727
http://dx.doi.org/10.1155/2012/707260
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author Piérard, Gérald E.
Piérard-Franchimont, Claudine
author_facet Piérard, Gérald E.
Piérard-Franchimont, Claudine
author_sort Piérard, Gérald E.
collection PubMed
description The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis. A series of genes of the four HOX gene clusters A, B, C, and D were reported to show aberrant expressions in oncogenesis, particularly in cutaneous malignant melanoma (CMM). They are involved in cell proliferation and progression in the CMM metastatic path. We present relevant peer-reviewed literature findings about the aberrant expression of HOX genes in CMM. The number of CMM cell nuclei exhibiting aberrant HOX protein expression appears correlated with tumour progression.
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spelling pubmed-34681272012-10-22 HOX Gene Aberrant Expression in Skin Melanoma: A Review Piérard, Gérald E. Piérard-Franchimont, Claudine J Skin Cancer Review Article The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis. A series of genes of the four HOX gene clusters A, B, C, and D were reported to show aberrant expressions in oncogenesis, particularly in cutaneous malignant melanoma (CMM). They are involved in cell proliferation and progression in the CMM metastatic path. We present relevant peer-reviewed literature findings about the aberrant expression of HOX genes in CMM. The number of CMM cell nuclei exhibiting aberrant HOX protein expression appears correlated with tumour progression. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3468127/ /pubmed/23091727 http://dx.doi.org/10.1155/2012/707260 Text en Copyright © 2012 G. E. Piérard and C. Piérard-Franchimont. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Piérard, Gérald E.
Piérard-Franchimont, Claudine
HOX Gene Aberrant Expression in Skin Melanoma: A Review
title HOX Gene Aberrant Expression in Skin Melanoma: A Review
title_full HOX Gene Aberrant Expression in Skin Melanoma: A Review
title_fullStr HOX Gene Aberrant Expression in Skin Melanoma: A Review
title_full_unstemmed HOX Gene Aberrant Expression in Skin Melanoma: A Review
title_short HOX Gene Aberrant Expression in Skin Melanoma: A Review
title_sort hox gene aberrant expression in skin melanoma: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468127/
https://www.ncbi.nlm.nih.gov/pubmed/23091727
http://dx.doi.org/10.1155/2012/707260
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