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Structural Basis of the Selective Block of Kv1.2 by Maurotoxin from Computer Simulations
The 34-residue polypeptide maurotoxin (MTx) isolated from scorpion venoms selectively inhibits the current of the voltage-gated potassium channel Kv1.2 by occluding the ion conduction pathway. Here using molecular dynamics simulation as a docking method, the binding modes of MTx to three closely rel...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468451/ https://www.ncbi.nlm.nih.gov/pubmed/23071772 http://dx.doi.org/10.1371/journal.pone.0047253 |