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RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies
OBJECTIVE: The G-403A polymorphism in RANTES gene may be involved in the development of coronary artery disease (CAD) through increasing RANTES-mediated leukocyte trafficking and activation. However, studies investigating the relationship between G-403A polymorphism and CAD yielded contradictory and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468465/ https://www.ncbi.nlm.nih.gov/pubmed/23071760 http://dx.doi.org/10.1371/journal.pone.0047211 |
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author | Liu, Jun Jia, Yan-Jun Li, Xiao-Lin Xu, Rui-Xa Zhu, Cheng-Gang Guo, Yuan-Lin Wu, Na-Qiong Li, Jian-Jun |
author_facet | Liu, Jun Jia, Yan-Jun Li, Xiao-Lin Xu, Rui-Xa Zhu, Cheng-Gang Guo, Yuan-Lin Wu, Na-Qiong Li, Jian-Jun |
author_sort | Liu, Jun |
collection | PubMed |
description | OBJECTIVE: The G-403A polymorphism in RANTES gene may be involved in the development of coronary artery disease (CAD) through increasing RANTES-mediated leukocyte trafficking and activation. However, studies investigating the relationship between G-403A polymorphism and CAD yielded contradictory and inconclusive results. In order to shed some light on these inconsistent findings, a meta analysis was performed to clarify the role of G-403A polymorphism of RANTES gene in the susceptibility of CAD. METHODS: A systemic literature search of PubMed and EMBASE was conducted from their inception to March 23, 2012, to retrieve related studies. In addition, Conference Proceedings Citation Index-Science was searched, authors of relevant studies were contacted, and reference lists of the included studies and their related citations in PubMed were reviewed for additional pertinent studies. RESULTS: A total of 8 eligible studies were identified, with a total of 4252 CAD cases and 2150 controls. There was no evidence of significant association between G-403A polymorphism and CAD risk in any genetic model or pairwise comparisons (additive model: OR = 1.046, 95% CI = 0.883–1.239, I(2) = 65.9%; recessive model: OR = 1.140, 95% CI = 0.774–1.678, I(2) = 53.1%; dominant model: OR = 1.000, 95% CI = 0.820–1.21), I(2) = 62.6%; AA vs GG: OR = 1.141, 95% CI = 0.734–1.773, I(2) = 61.2%; GA vs GG: OR = 0.993, 95% CI = 0.800–1.232, I(2) = 64.6%). Subgroup analysis and meta regression indicated that ethnicity and genotyping method accounted for the significant heterogeneity among studies. In the stratified analysis by ethnic group, G-403A polymorphism was found to be associated with increased CAD risk in Caucasian population whereas its protective role was observed in Asian population in some but not all comparisons. CONCLUSION: Data from the current meta-analysis do not support the existence of a relationship between G-403A polymorphism and the development of CAD, and large sample size study employing unified genotyping method is needed to further evaluate the influence of G-403A polymorphism on susceptibility of CAD. |
format | Online Article Text |
id | pubmed-3468465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34684652012-10-15 RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies Liu, Jun Jia, Yan-Jun Li, Xiao-Lin Xu, Rui-Xa Zhu, Cheng-Gang Guo, Yuan-Lin Wu, Na-Qiong Li, Jian-Jun PLoS One Research Article OBJECTIVE: The G-403A polymorphism in RANTES gene may be involved in the development of coronary artery disease (CAD) through increasing RANTES-mediated leukocyte trafficking and activation. However, studies investigating the relationship between G-403A polymorphism and CAD yielded contradictory and inconclusive results. In order to shed some light on these inconsistent findings, a meta analysis was performed to clarify the role of G-403A polymorphism of RANTES gene in the susceptibility of CAD. METHODS: A systemic literature search of PubMed and EMBASE was conducted from their inception to March 23, 2012, to retrieve related studies. In addition, Conference Proceedings Citation Index-Science was searched, authors of relevant studies were contacted, and reference lists of the included studies and their related citations in PubMed were reviewed for additional pertinent studies. RESULTS: A total of 8 eligible studies were identified, with a total of 4252 CAD cases and 2150 controls. There was no evidence of significant association between G-403A polymorphism and CAD risk in any genetic model or pairwise comparisons (additive model: OR = 1.046, 95% CI = 0.883–1.239, I(2) = 65.9%; recessive model: OR = 1.140, 95% CI = 0.774–1.678, I(2) = 53.1%; dominant model: OR = 1.000, 95% CI = 0.820–1.21), I(2) = 62.6%; AA vs GG: OR = 1.141, 95% CI = 0.734–1.773, I(2) = 61.2%; GA vs GG: OR = 0.993, 95% CI = 0.800–1.232, I(2) = 64.6%). Subgroup analysis and meta regression indicated that ethnicity and genotyping method accounted for the significant heterogeneity among studies. In the stratified analysis by ethnic group, G-403A polymorphism was found to be associated with increased CAD risk in Caucasian population whereas its protective role was observed in Asian population in some but not all comparisons. CONCLUSION: Data from the current meta-analysis do not support the existence of a relationship between G-403A polymorphism and the development of CAD, and large sample size study employing unified genotyping method is needed to further evaluate the influence of G-403A polymorphism on susceptibility of CAD. Public Library of Science 2012-10-10 /pmc/articles/PMC3468465/ /pubmed/23071760 http://dx.doi.org/10.1371/journal.pone.0047211 Text en © 2012 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Liu, Jun Jia, Yan-Jun Li, Xiao-Lin Xu, Rui-Xa Zhu, Cheng-Gang Guo, Yuan-Lin Wu, Na-Qiong Li, Jian-Jun RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies |
title | RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies |
title_full | RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies |
title_fullStr | RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies |
title_full_unstemmed | RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies |
title_short | RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies |
title_sort | rantes gene g-403a polymorphism and coronary artery disease: a meta analysis of observational studies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468465/ https://www.ncbi.nlm.nih.gov/pubmed/23071760 http://dx.doi.org/10.1371/journal.pone.0047211 |
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