Combinatorial Pharmacogenetic Interactions of Bucindolol and β(1), α(2C) Adrenergic Receptor Polymorphisms

BACKGROUND: Pharmacogenetics involves complex interactions of gene products affecting pharmacodynamics and pharmacokinetics, but there is little information on the interaction of multiple genetic modifiers of drug response. Bucindolol is a β-blocker/sympatholytic agent whose efficacy is modulated by...

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Detalles Bibliográficos
Autores principales: O'Connor, Christopher M., Fiuzat, Mona, Carson, Peter E., Anand, Inder S., Plehn, Jonathan F., Gottlieb, Stephen S., Silver, Marc A., Lindenfeld, JoAnn, Miller, Alan B., White, Michel, Walsh, Ryan, Nelson, Penny, Medway, Allen, Davis, Gordon, Robertson, Alastair D., Port, J. David, Carr, James, Murphy, Guinevere A., Lazzeroni, Laura C., Abraham, William T., Liggett, Stephen B., Bristow, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468617/
https://www.ncbi.nlm.nih.gov/pubmed/23071495
http://dx.doi.org/10.1371/journal.pone.0044324

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