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Association between Total Bilirubin and Hemoglobin A1c in Korean Type 2 Diabetic Patients

Recent studies have shown that bilirubin is negatively associated with hemoglobin A1c (HbA1c) in the general population. The association between bilirubin and HbA1c in serum of diabetes patients has not yet been studied. The aim of the present study was to evaluate the association between total bili...

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Autores principales: Choi, Seong-Woo, Lee, Young-Hoon, Kweon, Sun-Seog, Song, Hye-rim, Ahn, Hye-Ran, Rhee, Jung-Ae, Choi, Jin-Su, Shin, Min-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468756/
https://www.ncbi.nlm.nih.gov/pubmed/23091317
http://dx.doi.org/10.3346/jkms.2012.27.10.1196
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author Choi, Seong-Woo
Lee, Young-Hoon
Kweon, Sun-Seog
Song, Hye-rim
Ahn, Hye-Ran
Rhee, Jung-Ae
Choi, Jin-Su
Shin, Min-Ho
author_facet Choi, Seong-Woo
Lee, Young-Hoon
Kweon, Sun-Seog
Song, Hye-rim
Ahn, Hye-Ran
Rhee, Jung-Ae
Choi, Jin-Su
Shin, Min-Ho
author_sort Choi, Seong-Woo
collection PubMed
description Recent studies have shown that bilirubin is negatively associated with hemoglobin A1c (HbA1c) in the general population. The association between bilirubin and HbA1c in serum of diabetes patients has not yet been studied. The aim of the present study was to evaluate the association between total bilirubin and HbA1c in Korean patients with type 2 diabetes. A total of 690 of the 1,275 type 2 diabetes patients registered with the public health centers in Seo-gu, Gwangju and Gokseong-gun, Jeollanam-do participated in this study. Following an overnight fast, venous blood and urine samples were collected and analyzed. The mean HbA1c values differed significantly according to total bilirubin (≤ 0.4 mg/dL, 7.6%; 0.5 mg/dL, 7.3%; 0.6-0.7 mg/dL, 7.2%; and ≥ 0.8 mg/dL, 7.1%; P for trend = 0.016) after we adjusted for other confounding factors. When the odds ratio (OR) was adjusted for other confounding factors, there was a significant association between total bilirubin and HbA1c (OR, 0.4 [95% confidence interval, 0.2-0.8] for total bilirubin ≥ 0.8 mg/dL versus ≤ 0.4 mg/dL. In conclusion, total bilirubin concentrations in serum are negatively associated with HbA1c levels after adjustment for sex, age, and other confounding factors in type 2 diabetes patients.
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spelling pubmed-34687562012-10-22 Association between Total Bilirubin and Hemoglobin A1c in Korean Type 2 Diabetic Patients Choi, Seong-Woo Lee, Young-Hoon Kweon, Sun-Seog Song, Hye-rim Ahn, Hye-Ran Rhee, Jung-Ae Choi, Jin-Su Shin, Min-Ho J Korean Med Sci Original Article Recent studies have shown that bilirubin is negatively associated with hemoglobin A1c (HbA1c) in the general population. The association between bilirubin and HbA1c in serum of diabetes patients has not yet been studied. The aim of the present study was to evaluate the association between total bilirubin and HbA1c in Korean patients with type 2 diabetes. A total of 690 of the 1,275 type 2 diabetes patients registered with the public health centers in Seo-gu, Gwangju and Gokseong-gun, Jeollanam-do participated in this study. Following an overnight fast, venous blood and urine samples were collected and analyzed. The mean HbA1c values differed significantly according to total bilirubin (≤ 0.4 mg/dL, 7.6%; 0.5 mg/dL, 7.3%; 0.6-0.7 mg/dL, 7.2%; and ≥ 0.8 mg/dL, 7.1%; P for trend = 0.016) after we adjusted for other confounding factors. When the odds ratio (OR) was adjusted for other confounding factors, there was a significant association between total bilirubin and HbA1c (OR, 0.4 [95% confidence interval, 0.2-0.8] for total bilirubin ≥ 0.8 mg/dL versus ≤ 0.4 mg/dL. In conclusion, total bilirubin concentrations in serum are negatively associated with HbA1c levels after adjustment for sex, age, and other confounding factors in type 2 diabetes patients. The Korean Academy of Medical Sciences 2012-10 2012-10-02 /pmc/articles/PMC3468756/ /pubmed/23091317 http://dx.doi.org/10.3346/jkms.2012.27.10.1196 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Seong-Woo
Lee, Young-Hoon
Kweon, Sun-Seog
Song, Hye-rim
Ahn, Hye-Ran
Rhee, Jung-Ae
Choi, Jin-Su
Shin, Min-Ho
Association between Total Bilirubin and Hemoglobin A1c in Korean Type 2 Diabetic Patients
title Association between Total Bilirubin and Hemoglobin A1c in Korean Type 2 Diabetic Patients
title_full Association between Total Bilirubin and Hemoglobin A1c in Korean Type 2 Diabetic Patients
title_fullStr Association between Total Bilirubin and Hemoglobin A1c in Korean Type 2 Diabetic Patients
title_full_unstemmed Association between Total Bilirubin and Hemoglobin A1c in Korean Type 2 Diabetic Patients
title_short Association between Total Bilirubin and Hemoglobin A1c in Korean Type 2 Diabetic Patients
title_sort association between total bilirubin and hemoglobin a1c in korean type 2 diabetic patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468756/
https://www.ncbi.nlm.nih.gov/pubmed/23091317
http://dx.doi.org/10.3346/jkms.2012.27.10.1196
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