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Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer

PURPOSE: The purpose of this study is to evaluate the correlation between the conventional plan parameters and dosimetric parameters obtained from conformal radiotherapy (RT) planning, and between these parameters and radiation pneumontitis (RP) incidence. METHODS: Clinical and dosimetric data of 12...

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Autores principales: Onal, Cem, Oymak, Ezgi, Kotek, Ayse, Efe, Esma, Arslan, Gungor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Breast Cancer Society 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468786/
https://www.ncbi.nlm.nih.gov/pubmed/23091545
http://dx.doi.org/10.4048/jbc.2012.15.3.320
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author Onal, Cem
Oymak, Ezgi
Kotek, Ayse
Efe, Esma
Arslan, Gungor
author_facet Onal, Cem
Oymak, Ezgi
Kotek, Ayse
Efe, Esma
Arslan, Gungor
author_sort Onal, Cem
collection PubMed
description PURPOSE: The purpose of this study is to evaluate the correlation between the conventional plan parameters and dosimetric parameters obtained from conformal radiotherapy (RT) planning, and between these parameters and radiation pneumontitis (RP) incidence. METHODS: Clinical and dosimetric data of 122 patients that were treated with mastectomy and adjuvant 3D conformal RT (39% received 2-field RT [2-FRT], and in addition, 61% received 4-field RT [4-FRT]) were retrospectively analyzed. Central lung depth (CLD), maximum lung depth (MLD), and lung length were measured by the conventional plan. Lung dose-volume histograms (DVH) were created with conformal planning, and the lung volumes receiving 5 to 50 Gy (V(5Gy) to V(50Gy)) were calculated. Minimum (D(min)), maximum (D(max)), and mean doses (D(mean)) for the ipsilateral lung and bilateral lungs were measured by DVH. Correlations between 3D dosimetric data and 2D radiographic parameters were analyzed. RESULTS: The conventional plan parameters did not significantly differ between 2-FRT and 4-FRT. The conformal plan D(min), D(max), and D(mean) values were higher in 4-FRT versus 2-FRT. CLD and MLD were correlated with DVH parameter V(5Gy) to V(45Gy) values for ipsilateral, as well as bilateral lungs for 2-FRT. MLD and ipsilateral D(mean) via 2-FRT planning had the strongest positive correlation (r=0.76, p<0.01). Moderate correlations existed between CLD and ipsilateral and bilateral lung V(5Gy-45Gy), and between MLD and bilateral lung V(5Gy-45Gy) values in 2-FRT. Only four patients developed symptomatic RP, 4 with 4-FRT and one with 2-FRT. CONCLUSION: The conformal plan parameters were strongly correlated with dose-volume parameters for breast 2-FRT. With only 4 cases of Grade 3 RP observed, our study is limited in its ability to provide definitive guidance, however assuming that CLD is an indicator for RP, V(20Gy) could be used as a predictor for RP and for 2-FRT. A well-defined parameters are still required to predict RP in 4-FRT.
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spelling pubmed-34687862012-10-22 Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer Onal, Cem Oymak, Ezgi Kotek, Ayse Efe, Esma Arslan, Gungor J Breast Cancer Original Article PURPOSE: The purpose of this study is to evaluate the correlation between the conventional plan parameters and dosimetric parameters obtained from conformal radiotherapy (RT) planning, and between these parameters and radiation pneumontitis (RP) incidence. METHODS: Clinical and dosimetric data of 122 patients that were treated with mastectomy and adjuvant 3D conformal RT (39% received 2-field RT [2-FRT], and in addition, 61% received 4-field RT [4-FRT]) were retrospectively analyzed. Central lung depth (CLD), maximum lung depth (MLD), and lung length were measured by the conventional plan. Lung dose-volume histograms (DVH) were created with conformal planning, and the lung volumes receiving 5 to 50 Gy (V(5Gy) to V(50Gy)) were calculated. Minimum (D(min)), maximum (D(max)), and mean doses (D(mean)) for the ipsilateral lung and bilateral lungs were measured by DVH. Correlations between 3D dosimetric data and 2D radiographic parameters were analyzed. RESULTS: The conventional plan parameters did not significantly differ between 2-FRT and 4-FRT. The conformal plan D(min), D(max), and D(mean) values were higher in 4-FRT versus 2-FRT. CLD and MLD were correlated with DVH parameter V(5Gy) to V(45Gy) values for ipsilateral, as well as bilateral lungs for 2-FRT. MLD and ipsilateral D(mean) via 2-FRT planning had the strongest positive correlation (r=0.76, p<0.01). Moderate correlations existed between CLD and ipsilateral and bilateral lung V(5Gy-45Gy), and between MLD and bilateral lung V(5Gy-45Gy) values in 2-FRT. Only four patients developed symptomatic RP, 4 with 4-FRT and one with 2-FRT. CONCLUSION: The conformal plan parameters were strongly correlated with dose-volume parameters for breast 2-FRT. With only 4 cases of Grade 3 RP observed, our study is limited in its ability to provide definitive guidance, however assuming that CLD is an indicator for RP, V(20Gy) could be used as a predictor for RP and for 2-FRT. A well-defined parameters are still required to predict RP in 4-FRT. Korean Breast Cancer Society 2012-09 2012-09-28 /pmc/articles/PMC3468786/ /pubmed/23091545 http://dx.doi.org/10.4048/jbc.2012.15.3.320 Text en © 2012 Korean Breast Cancer Society. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Onal, Cem
Oymak, Ezgi
Kotek, Ayse
Efe, Esma
Arslan, Gungor
Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer
title Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer
title_full Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer
title_fullStr Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer
title_full_unstemmed Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer
title_short Correlation of Conventional and Conformal Plan Parameters for Predicting Radiation Pneumonitis in Patients Treated with Breast Cancer
title_sort correlation of conventional and conformal plan parameters for predicting radiation pneumonitis in patients treated with breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468786/
https://www.ncbi.nlm.nih.gov/pubmed/23091545
http://dx.doi.org/10.4048/jbc.2012.15.3.320
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