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The Effects of Vitamins E and D Supplementation on Erythrocyte Superoxide Dismutase and Catalase in Atopic Dermatitis

BACKGROUND: Atopic dermatitis is a public health problem worldwide. Increment of reactive oxygen species (ROS) production may be one of the contributing factors of tissue damage in atopic dermatitis. The present study was designed to determine the effect of vitamins E and/or D on erythrocyte superox...

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Autores principales: Javanbakht, MH, Keshavarz, SA, Mirshafiey, A, Djalali, M, Siassi, F, Eshraghian, MR, Firooz, AR, Seirafi, H, Ehsani, AH, Chamari, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468963/
https://www.ncbi.nlm.nih.gov/pubmed/23112990
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author Javanbakht, MH
Keshavarz, SA
Mirshafiey, A
Djalali, M
Siassi, F
Eshraghian, MR
Firooz, AR
Seirafi, H
Ehsani, AH
Chamari, M
author_facet Javanbakht, MH
Keshavarz, SA
Mirshafiey, A
Djalali, M
Siassi, F
Eshraghian, MR
Firooz, AR
Seirafi, H
Ehsani, AH
Chamari, M
author_sort Javanbakht, MH
collection PubMed
description BACKGROUND: Atopic dermatitis is a public health problem worldwide. Increment of reactive oxygen species (ROS) production may be one of the contributing factors of tissue damage in atopic dermatitis. The present study was designed to determine the effect of vitamins E and/or D on erythrocyte superoxide dismutase and catalase activities in patients with atopic dermatitis. METHODS: In a randomized, double blind, placebo controlled clinical trial 45 atopic dermatitis patients were divided into four groups. Each group received one of the following supplements for 60 days: group A (n=11) vitamins E and D placebos; group B (n= 12) 1600 international unit (IU) vitamin D3 plus vitamin E placebo; group C (n=11) 600 IU synthetic all-rac-α tocopherol plus vitamin D placebo; group D (n=11) 1600 IU vitamin D3 plus 600 IU synthetic all-rac-α tocopherol. Erythrocyte superoxide dismutase (SOD) and catalase activities, serum 25 (OH) D, plasma α-tocopherol were determined. The data were analyzed by analysis of variance (ANOVA) and paired t-test. RESULTS: After 60 days vitamin D and E supplementation, erythrocyte SOD activities increased in groups B, C and D (P= 0.002, P= 0.016 and P= 0.015, respectively). Erythrocyte catalase activities increased in groups B and D (P= 0.026 and P= 0.004, respectively). The increment of erythrocyte catalase activity was not significant in group C. There was a positive significant correlation between SOD activity and serum 25 (OH) D (r= 0.378, P= 0.01). CONCLUSIONS: It is concluded that vitamin D is as potent as vitamin E in increasing the activities of erythrocyte SOD and catalase in atopic dermatitis patients.
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spelling pubmed-34689632012-10-30 The Effects of Vitamins E and D Supplementation on Erythrocyte Superoxide Dismutase and Catalase in Atopic Dermatitis Javanbakht, MH Keshavarz, SA Mirshafiey, A Djalali, M Siassi, F Eshraghian, MR Firooz, AR Seirafi, H Ehsani, AH Chamari, M Iran J Public Health Original Article BACKGROUND: Atopic dermatitis is a public health problem worldwide. Increment of reactive oxygen species (ROS) production may be one of the contributing factors of tissue damage in atopic dermatitis. The present study was designed to determine the effect of vitamins E and/or D on erythrocyte superoxide dismutase and catalase activities in patients with atopic dermatitis. METHODS: In a randomized, double blind, placebo controlled clinical trial 45 atopic dermatitis patients were divided into four groups. Each group received one of the following supplements for 60 days: group A (n=11) vitamins E and D placebos; group B (n= 12) 1600 international unit (IU) vitamin D3 plus vitamin E placebo; group C (n=11) 600 IU synthetic all-rac-α tocopherol plus vitamin D placebo; group D (n=11) 1600 IU vitamin D3 plus 600 IU synthetic all-rac-α tocopherol. Erythrocyte superoxide dismutase (SOD) and catalase activities, serum 25 (OH) D, plasma α-tocopherol were determined. The data were analyzed by analysis of variance (ANOVA) and paired t-test. RESULTS: After 60 days vitamin D and E supplementation, erythrocyte SOD activities increased in groups B, C and D (P= 0.002, P= 0.016 and P= 0.015, respectively). Erythrocyte catalase activities increased in groups B and D (P= 0.026 and P= 0.004, respectively). The increment of erythrocyte catalase activity was not significant in group C. There was a positive significant correlation between SOD activity and serum 25 (OH) D (r= 0.378, P= 0.01). CONCLUSIONS: It is concluded that vitamin D is as potent as vitamin E in increasing the activities of erythrocyte SOD and catalase in atopic dermatitis patients. Tehran University of Medical Sciences 2010-03-31 /pmc/articles/PMC3468963/ /pubmed/23112990 Text en Copyright © Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Javanbakht, MH
Keshavarz, SA
Mirshafiey, A
Djalali, M
Siassi, F
Eshraghian, MR
Firooz, AR
Seirafi, H
Ehsani, AH
Chamari, M
The Effects of Vitamins E and D Supplementation on Erythrocyte Superoxide Dismutase and Catalase in Atopic Dermatitis
title The Effects of Vitamins E and D Supplementation on Erythrocyte Superoxide Dismutase and Catalase in Atopic Dermatitis
title_full The Effects of Vitamins E and D Supplementation on Erythrocyte Superoxide Dismutase and Catalase in Atopic Dermatitis
title_fullStr The Effects of Vitamins E and D Supplementation on Erythrocyte Superoxide Dismutase and Catalase in Atopic Dermatitis
title_full_unstemmed The Effects of Vitamins E and D Supplementation on Erythrocyte Superoxide Dismutase and Catalase in Atopic Dermatitis
title_short The Effects of Vitamins E and D Supplementation on Erythrocyte Superoxide Dismutase and Catalase in Atopic Dermatitis
title_sort effects of vitamins e and d supplementation on erythrocyte superoxide dismutase and catalase in atopic dermatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468963/
https://www.ncbi.nlm.nih.gov/pubmed/23112990
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