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Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children

BACKGROUND: Determination of reference ranges of each serum protein in normal population of each country is required for studies and clinical interpretation. The aim of this study was defining reference range values of immunoglobulins and complement components in Iranian healthy children. METHODS: T...

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Autores principales: Kardar, GA, Oraei, M, Shahsavani, M, Namdar, Z, Kazemisefat, GE, Haghi Ashtiani, MT, Shams, S, Pourpak, Z, Moin, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469020/
https://www.ncbi.nlm.nih.gov/pubmed/23113211
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author Kardar, GA
Oraei, M
Shahsavani, M
Namdar, Z
Kazemisefat, GE
Haghi Ashtiani, MT
Shams, S
Pourpak, Z
Moin, M
author_facet Kardar, GA
Oraei, M
Shahsavani, M
Namdar, Z
Kazemisefat, GE
Haghi Ashtiani, MT
Shams, S
Pourpak, Z
Moin, M
author_sort Kardar, GA
collection PubMed
description BACKGROUND: Determination of reference ranges of each serum protein in normal population of each country is required for studies and clinical interpretation. The aim of this study was defining reference range values of immunoglobulins and complement components in Iranian healthy children. METHODS: This study was conducted from June 2003 to June 2006 in Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences. Serum levels of IgG, IgM, IgA, C3 and C4 in 800 Iranian healthy children from newborn to 18 years of age in four population were measured by nephelometry. Kolmogrov-Smirnov tests and Pearson correlation tests were used for analysis. RESULTS: Our results mainly agree with previous reports, except for some discrepancy that might be due to the ethnic and geographic variety. There was a significant difference between two sexes only with IgA in the group of 1–3 months old, which was higher in male group and IgM in groups of 3–5, 6–8 and 9–11 years old that were higher in female groups. Mean of other serum immunoglobulins and complements was not significantly different between male and female groups. CONCLUSION: These results can be considered as a local reference for use in laboratories, clinical interpretations, and research for Iranian children.
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spelling pubmed-34690202012-10-30 Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children Kardar, GA Oraei, M Shahsavani, M Namdar, Z Kazemisefat, GE Haghi Ashtiani, MT Shams, S Pourpak, Z Moin, M Iran J Public Health Original Article BACKGROUND: Determination of reference ranges of each serum protein in normal population of each country is required for studies and clinical interpretation. The aim of this study was defining reference range values of immunoglobulins and complement components in Iranian healthy children. METHODS: This study was conducted from June 2003 to June 2006 in Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences. Serum levels of IgG, IgM, IgA, C3 and C4 in 800 Iranian healthy children from newborn to 18 years of age in four population were measured by nephelometry. Kolmogrov-Smirnov tests and Pearson correlation tests were used for analysis. RESULTS: Our results mainly agree with previous reports, except for some discrepancy that might be due to the ethnic and geographic variety. There was a significant difference between two sexes only with IgA in the group of 1–3 months old, which was higher in male group and IgM in groups of 3–5, 6–8 and 9–11 years old that were higher in female groups. Mean of other serum immunoglobulins and complements was not significantly different between male and female groups. CONCLUSION: These results can be considered as a local reference for use in laboratories, clinical interpretations, and research for Iranian children. Tehran University of Medical Sciences 2012-07-31 /pmc/articles/PMC3469020/ /pubmed/23113211 Text en Copyright © Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Kardar, GA
Oraei, M
Shahsavani, M
Namdar, Z
Kazemisefat, GE
Haghi Ashtiani, MT
Shams, S
Pourpak, Z
Moin, M
Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children
title Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children
title_full Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children
title_fullStr Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children
title_full_unstemmed Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children
title_short Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children
title_sort reference intervals for serum immunoglobulins igg, iga, igm and complements c3 and c4 in iranian healthy children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469020/
https://www.ncbi.nlm.nih.gov/pubmed/23113211
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