Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model

BACKGROUND: Cutaneous leishmaniasis caused by L. major is an important public health problem in endemic areas. The aim of this study was to explore the therapeutic effect of microwave and or infrared radiation in the treatment of lesion induced in BALB/c mice by L. major inoculation. METHODS: The fo...

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Autores principales: Eskandari, SE, Azimzadeh, A, Bahar, M, Naraghi, Z Safai, Javadi, A, Khamesipour, A, Mohamadi, A Miramin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469029/
https://www.ncbi.nlm.nih.gov/pubmed/23113229
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author Eskandari, SE
Azimzadeh, A
Bahar, M
Naraghi, Z Safai
Javadi, A
Khamesipour, A
Mohamadi, A Miramin
author_facet Eskandari, SE
Azimzadeh, A
Bahar, M
Naraghi, Z Safai
Javadi, A
Khamesipour, A
Mohamadi, A Miramin
author_sort Eskandari, SE
collection PubMed
description BACKGROUND: Cutaneous leishmaniasis caused by L. major is an important public health problem in endemic areas. The aim of this study was to explore the therapeutic effect of microwave and or infrared radiation in the treatment of lesion induced in BALB/c mice by L. major inoculation. METHODS: The footpad lesion was induced in BALB/c mice by inoculation of L. major promastigotes subcutaneously. The lesion was treated with 600 watts power, 2.450 GHz frequency and/or infrared device with 150 watts and a wave length of 890 nanometres. The size of the lesion was recorded by footpad swelling measurement every 10 days. RESULTS: The lesion growth was significantly hampered in treated mice compared with the untreated control group (P<0.05). Infrared radiation was more effective than microwave in inhibiting ulcer enlargement. CONCLUSION: Infrared radiation and microwave significantly hampered L. major lesion growth in BALB/c mice. This therapeutic effect was more in infrared radiation treated mice than microwave treated mice.
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spelling pubmed-34690292012-10-30 Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model Eskandari, SE Azimzadeh, A Bahar, M Naraghi, Z Safai Javadi, A Khamesipour, A Mohamadi, A Miramin Iran J Public Health Original Article BACKGROUND: Cutaneous leishmaniasis caused by L. major is an important public health problem in endemic areas. The aim of this study was to explore the therapeutic effect of microwave and or infrared radiation in the treatment of lesion induced in BALB/c mice by L. major inoculation. METHODS: The footpad lesion was induced in BALB/c mice by inoculation of L. major promastigotes subcutaneously. The lesion was treated with 600 watts power, 2.450 GHz frequency and/or infrared device with 150 watts and a wave length of 890 nanometres. The size of the lesion was recorded by footpad swelling measurement every 10 days. RESULTS: The lesion growth was significantly hampered in treated mice compared with the untreated control group (P<0.05). Infrared radiation was more effective than microwave in inhibiting ulcer enlargement. CONCLUSION: Infrared radiation and microwave significantly hampered L. major lesion growth in BALB/c mice. This therapeutic effect was more in infrared radiation treated mice than microwave treated mice. Tehran University of Medical Sciences 2012-08-31 /pmc/articles/PMC3469029/ /pubmed/23113229 Text en Copyright © Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Eskandari, SE
Azimzadeh, A
Bahar, M
Naraghi, Z Safai
Javadi, A
Khamesipour, A
Mohamadi, A Miramin
Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model
title Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model
title_full Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model
title_fullStr Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model
title_full_unstemmed Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model
title_short Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model
title_sort efficacy of microwave and infrared radiation in the treatment of the skin lesions caused by leishmania major in an animal model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469029/
https://www.ncbi.nlm.nih.gov/pubmed/23113229
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