Cargando…

Recurrent Thrombotic Thrombocytopenic Purpura-Like Syndrome as a Paraneoplastic Phenomenon in Malignant Peritoneal Mesothelioma: A Case Report and Review of the Literature

We report the case of an African American male with no significant past medical history presenting with recurrent, rapidly relapsing episodes of thrombotic thrombocytopenic purpura (TTP) despite aggressive treatment with several lines of treatment. Incidentally, these episodes were associated with s...

Descripción completa

Detalles Bibliográficos
Autores principales: Socola, Francisco, Loaiza-Bonilla, Arturo, Bustinza-Linares, Ernesto, Correa, Ricardo, Rosenblatt, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469074/
https://www.ncbi.nlm.nih.gov/pubmed/23082261
http://dx.doi.org/10.1155/2012/619348
_version_ 1782246031293939712
author Socola, Francisco
Loaiza-Bonilla, Arturo
Bustinza-Linares, Ernesto
Correa, Ricardo
Rosenblatt, Joseph D.
author_facet Socola, Francisco
Loaiza-Bonilla, Arturo
Bustinza-Linares, Ernesto
Correa, Ricardo
Rosenblatt, Joseph D.
author_sort Socola, Francisco
collection PubMed
description We report the case of an African American male with no significant past medical history presenting with recurrent, rapidly relapsing episodes of thrombotic thrombocytopenic purpura (TTP) despite aggressive treatment with several lines of treatment. Incidentally, these episodes were associated with severe abdominal pain which eventually developed into acute abdomen and prompted exploratory laparotomy, revealing diffuse carcinomatosis with a tumor located on the left pelvis that was encasing the distal sigmoid colon. Pathology made a final diagnosis of peritoneal mesothelioma. TTP-like syndrome (TTP-LS) has been described as a paraneoplastic phenomenon in several malignancies but never before in the setting of malignant mesothelioma. Paraneoplastic TTP-like syndrome has historically been associated with a dismal prognosis and particular clinical and laboratory abnormalities described in this paper. It is of utmost importance to make a prompt determination whether TTP is idiopathic or secondary to an underlying condition because of significant differences in their prognosis, treatment, and response. This paper also reviews the current literature regarding this challenging condition.
format Online
Article
Text
id pubmed-3469074
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34690742012-10-18 Recurrent Thrombotic Thrombocytopenic Purpura-Like Syndrome as a Paraneoplastic Phenomenon in Malignant Peritoneal Mesothelioma: A Case Report and Review of the Literature Socola, Francisco Loaiza-Bonilla, Arturo Bustinza-Linares, Ernesto Correa, Ricardo Rosenblatt, Joseph D. Case Rep Oncol Med Case Report We report the case of an African American male with no significant past medical history presenting with recurrent, rapidly relapsing episodes of thrombotic thrombocytopenic purpura (TTP) despite aggressive treatment with several lines of treatment. Incidentally, these episodes were associated with severe abdominal pain which eventually developed into acute abdomen and prompted exploratory laparotomy, revealing diffuse carcinomatosis with a tumor located on the left pelvis that was encasing the distal sigmoid colon. Pathology made a final diagnosis of peritoneal mesothelioma. TTP-like syndrome (TTP-LS) has been described as a paraneoplastic phenomenon in several malignancies but never before in the setting of malignant mesothelioma. Paraneoplastic TTP-like syndrome has historically been associated with a dismal prognosis and particular clinical and laboratory abnormalities described in this paper. It is of utmost importance to make a prompt determination whether TTP is idiopathic or secondary to an underlying condition because of significant differences in their prognosis, treatment, and response. This paper also reviews the current literature regarding this challenging condition. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3469074/ /pubmed/23082261 http://dx.doi.org/10.1155/2012/619348 Text en Copyright © 2012 Francisco Socola et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Socola, Francisco
Loaiza-Bonilla, Arturo
Bustinza-Linares, Ernesto
Correa, Ricardo
Rosenblatt, Joseph D.
Recurrent Thrombotic Thrombocytopenic Purpura-Like Syndrome as a Paraneoplastic Phenomenon in Malignant Peritoneal Mesothelioma: A Case Report and Review of the Literature
title Recurrent Thrombotic Thrombocytopenic Purpura-Like Syndrome as a Paraneoplastic Phenomenon in Malignant Peritoneal Mesothelioma: A Case Report and Review of the Literature
title_full Recurrent Thrombotic Thrombocytopenic Purpura-Like Syndrome as a Paraneoplastic Phenomenon in Malignant Peritoneal Mesothelioma: A Case Report and Review of the Literature
title_fullStr Recurrent Thrombotic Thrombocytopenic Purpura-Like Syndrome as a Paraneoplastic Phenomenon in Malignant Peritoneal Mesothelioma: A Case Report and Review of the Literature
title_full_unstemmed Recurrent Thrombotic Thrombocytopenic Purpura-Like Syndrome as a Paraneoplastic Phenomenon in Malignant Peritoneal Mesothelioma: A Case Report and Review of the Literature
title_short Recurrent Thrombotic Thrombocytopenic Purpura-Like Syndrome as a Paraneoplastic Phenomenon in Malignant Peritoneal Mesothelioma: A Case Report and Review of the Literature
title_sort recurrent thrombotic thrombocytopenic purpura-like syndrome as a paraneoplastic phenomenon in malignant peritoneal mesothelioma: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469074/
https://www.ncbi.nlm.nih.gov/pubmed/23082261
http://dx.doi.org/10.1155/2012/619348
work_keys_str_mv AT socolafrancisco recurrentthromboticthrombocytopenicpurpuralikesyndromeasaparaneoplasticphenomenoninmalignantperitonealmesotheliomaacasereportandreviewoftheliterature
AT loaizabonillaarturo recurrentthromboticthrombocytopenicpurpuralikesyndromeasaparaneoplasticphenomenoninmalignantperitonealmesotheliomaacasereportandreviewoftheliterature
AT bustinzalinaresernesto recurrentthromboticthrombocytopenicpurpuralikesyndromeasaparaneoplasticphenomenoninmalignantperitonealmesotheliomaacasereportandreviewoftheliterature
AT correaricardo recurrentthromboticthrombocytopenicpurpuralikesyndromeasaparaneoplasticphenomenoninmalignantperitonealmesotheliomaacasereportandreviewoftheliterature
AT rosenblattjosephd recurrentthromboticthrombocytopenicpurpuralikesyndromeasaparaneoplasticphenomenoninmalignantperitonealmesotheliomaacasereportandreviewoftheliterature