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Incidence of Occult Carcinoma and High-Risk Lesions in Mammaplasty Specimens

Objectives. To determine the incidence and type of premalignant or malignant changes in mammaplasty specimens and to determine the incidence of these changes according to age distribution. Methods. Retrospective database review of patients who underwent a reduction mammaplasty between 1999 and 2009...

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Autores principales: Freedman, Beth C., Smith, Sharon M. Rosenbaum, Estabrook, Alison, Balderacchi, Jasminka, Tartter, Paul I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469090/
https://www.ncbi.nlm.nih.gov/pubmed/23091731
http://dx.doi.org/10.1155/2012/145630
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author Freedman, Beth C.
Smith, Sharon M. Rosenbaum
Estabrook, Alison
Balderacchi, Jasminka
Tartter, Paul I.
author_facet Freedman, Beth C.
Smith, Sharon M. Rosenbaum
Estabrook, Alison
Balderacchi, Jasminka
Tartter, Paul I.
author_sort Freedman, Beth C.
collection PubMed
description Objectives. To determine the incidence and type of premalignant or malignant changes in mammaplasty specimens and to determine the incidence of these changes according to age distribution. Methods. Retrospective database review of patients who underwent a reduction mammaplasty between 1999 and 2009 was performed from pathology records at a single institution. Results. 700 patients were identified. Of the 644 patients who had bilateral reductions, 25 (4%) had significant pathologic findings. The likelihood of finding premalignant changes or cancer increased with advancing patient age (0.8 percent for patients <40 years old and 10 percent for patients >60 years old). Of the 56 patients who underwent unilateral mammaplasty, 12 patients (21%) had significant pathologic findings. The incidence of finding premalignant changes or cancer in this population also increased with advancing patient age (0 for patients <40 years old to 25 percent for patients >60 years old). Conclusions. When a unilateral mammaplasty is performed to match a breast reconstructed after cancer surgery, the likelihood of identifying premalignant changes or cancer increases more than fourfold. Therefore, one should consider additional radiologic imaging in the preoperative workup of patients with a history of carcinoma prior to undergoing unilateral mammaplasty.
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spelling pubmed-34690902012-10-22 Incidence of Occult Carcinoma and High-Risk Lesions in Mammaplasty Specimens Freedman, Beth C. Smith, Sharon M. Rosenbaum Estabrook, Alison Balderacchi, Jasminka Tartter, Paul I. Int J Breast Cancer Research Article Objectives. To determine the incidence and type of premalignant or malignant changes in mammaplasty specimens and to determine the incidence of these changes according to age distribution. Methods. Retrospective database review of patients who underwent a reduction mammaplasty between 1999 and 2009 was performed from pathology records at a single institution. Results. 700 patients were identified. Of the 644 patients who had bilateral reductions, 25 (4%) had significant pathologic findings. The likelihood of finding premalignant changes or cancer increased with advancing patient age (0.8 percent for patients <40 years old and 10 percent for patients >60 years old). Of the 56 patients who underwent unilateral mammaplasty, 12 patients (21%) had significant pathologic findings. The incidence of finding premalignant changes or cancer in this population also increased with advancing patient age (0 for patients <40 years old to 25 percent for patients >60 years old). Conclusions. When a unilateral mammaplasty is performed to match a breast reconstructed after cancer surgery, the likelihood of identifying premalignant changes or cancer increases more than fourfold. Therefore, one should consider additional radiologic imaging in the preoperative workup of patients with a history of carcinoma prior to undergoing unilateral mammaplasty. Hindawi Publishing Corporation 2012 2012-10-03 /pmc/articles/PMC3469090/ /pubmed/23091731 http://dx.doi.org/10.1155/2012/145630 Text en Copyright © 2012 Beth C. Freedman et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Freedman, Beth C.
Smith, Sharon M. Rosenbaum
Estabrook, Alison
Balderacchi, Jasminka
Tartter, Paul I.
Incidence of Occult Carcinoma and High-Risk Lesions in Mammaplasty Specimens
title Incidence of Occult Carcinoma and High-Risk Lesions in Mammaplasty Specimens
title_full Incidence of Occult Carcinoma and High-Risk Lesions in Mammaplasty Specimens
title_fullStr Incidence of Occult Carcinoma and High-Risk Lesions in Mammaplasty Specimens
title_full_unstemmed Incidence of Occult Carcinoma and High-Risk Lesions in Mammaplasty Specimens
title_short Incidence of Occult Carcinoma and High-Risk Lesions in Mammaplasty Specimens
title_sort incidence of occult carcinoma and high-risk lesions in mammaplasty specimens
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469090/
https://www.ncbi.nlm.nih.gov/pubmed/23091731
http://dx.doi.org/10.1155/2012/145630
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