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Update on triple-negative breast cancer: prognosis and management strategies

Triple negative breast cancer (TNBC) is a heterogeneous disease comprehending different orphan breast cancers simply defined by the absence of ER/PR/HER-2. Approximately 15%–20% of all breast cancers belong to this phenotype that has distinct risk factors, distinct molecular features, and a particul...

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Detalles Bibliográficos
Autores principales: Brouckaert, Olivier, Wildiers, Hans, Floris, Giuseppe, Neven, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469230/
https://www.ncbi.nlm.nih.gov/pubmed/23071421
http://dx.doi.org/10.2147/IJWH.S18541
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author Brouckaert, Olivier
Wildiers, Hans
Floris, Giuseppe
Neven, Patrick
author_facet Brouckaert, Olivier
Wildiers, Hans
Floris, Giuseppe
Neven, Patrick
author_sort Brouckaert, Olivier
collection PubMed
description Triple negative breast cancer (TNBC) is a heterogeneous disease comprehending different orphan breast cancers simply defined by the absence of ER/PR/HER-2. Approximately 15%–20% of all breast cancers belong to this phenotype that has distinct risk factors, distinct molecular features, and a particular clinical presentation and outcome. All these features will be discussed in this review. The risk of developing TNBC varies with age, race, genetics, breastfeeding patterns, and parity. Some TNBC are very chemo-sensitive and the majority of patients confronted with and treated for TNBC will never relapse. Some (histological) subgroups of TNBC may have good prognosis even in the absence of chemotherapy. Distinct molecular subgroups within TNBC have been defined now as well. In case metastatic relapse occurs, this is usually within 5 years following surgery, and survival following metastatic relapse is shorter compared to other breast cancer subtypes; treatment options are few and responses lack durability. Novel drug targets and new biomarkers are needed to improve breast cancer care for patients presenting with TNBC. Further molecular/biological unraveling of TNBC is needed.
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spelling pubmed-34692302012-10-15 Update on triple-negative breast cancer: prognosis and management strategies Brouckaert, Olivier Wildiers, Hans Floris, Giuseppe Neven, Patrick Int J Womens Health Review Triple negative breast cancer (TNBC) is a heterogeneous disease comprehending different orphan breast cancers simply defined by the absence of ER/PR/HER-2. Approximately 15%–20% of all breast cancers belong to this phenotype that has distinct risk factors, distinct molecular features, and a particular clinical presentation and outcome. All these features will be discussed in this review. The risk of developing TNBC varies with age, race, genetics, breastfeeding patterns, and parity. Some TNBC are very chemo-sensitive and the majority of patients confronted with and treated for TNBC will never relapse. Some (histological) subgroups of TNBC may have good prognosis even in the absence of chemotherapy. Distinct molecular subgroups within TNBC have been defined now as well. In case metastatic relapse occurs, this is usually within 5 years following surgery, and survival following metastatic relapse is shorter compared to other breast cancer subtypes; treatment options are few and responses lack durability. Novel drug targets and new biomarkers are needed to improve breast cancer care for patients presenting with TNBC. Further molecular/biological unraveling of TNBC is needed. Dove Medical Press 2012-09-24 /pmc/articles/PMC3469230/ /pubmed/23071421 http://dx.doi.org/10.2147/IJWH.S18541 Text en © 2012 Brouckaert et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Brouckaert, Olivier
Wildiers, Hans
Floris, Giuseppe
Neven, Patrick
Update on triple-negative breast cancer: prognosis and management strategies
title Update on triple-negative breast cancer: prognosis and management strategies
title_full Update on triple-negative breast cancer: prognosis and management strategies
title_fullStr Update on triple-negative breast cancer: prognosis and management strategies
title_full_unstemmed Update on triple-negative breast cancer: prognosis and management strategies
title_short Update on triple-negative breast cancer: prognosis and management strategies
title_sort update on triple-negative breast cancer: prognosis and management strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469230/
https://www.ncbi.nlm.nih.gov/pubmed/23071421
http://dx.doi.org/10.2147/IJWH.S18541
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