Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis

Many malignancies show increased expression of the EGF receptor family member ErbB3 (HER3). ErbB3 binds beta-1 (HRGβ1), and forms a heterodimer with other ErbB family members, such as ErbB2 (HER2) or EGFR (HER1), enhancing phosphorylation of specific C terminal tyrosine residues and activation of do...

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Detalles Bibliográficos
Autores principales: Smirnova, Tatiana, Zhou, Zhen Ni, Flinn, Rory J., Wyckoff, Jeffrey, Boimel, Pamela J., Pozzuto, Maria, Coniglio, Salvatore J., Backer, Jonathan M., Bresnick, Anne R., Condeelis, John S., Hynes, Nancy E., Segall, Jeffrey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469325/
https://www.ncbi.nlm.nih.gov/pubmed/21725367
http://dx.doi.org/10.1038/onc.2011.275

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