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A mechanistic basis for amplification differences between samples and between genome regions

BACKGROUND: For many analytical methods the efficiency of DNA amplification varies across the genome and between samples. The most affected genome regions tend to correlate with high C + G content, however this relationship is complex and does not explain why the direction and magnitude of effects v...

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Detalles Bibliográficos
Autores principales:	Veal, Colin D, Freeman, Peter J, Jacobs, Kevin, Lancaster, Owen, Jamain, Stéphane, Leboyer, Marion, Albanes, Demetrius, Vaghela, Reshma R, Gut, Ivo, Chanock, Stephen J, Brookes, Anthony J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469336/ https://www.ncbi.nlm.nih.gov/pubmed/22950736 http://dx.doi.org/10.1186/1471-2164-13-455

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