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Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the primary leading strand replicase, whereas Pols α and δ primarily perform lagging strand replication. The fact that these po...

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Detalles Bibliográficos
Autores principales:	Lujan, Scott A., Williams, Jessica S., Pursell, Zachary F., Abdulovic-Cui, Amy A., Clark, Alan B., Nick McElhinny, Stephanie A., Kunkel, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469411/ https://www.ncbi.nlm.nih.gov/pubmed/23071460 http://dx.doi.org/10.1371/journal.pgen.1003016

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