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Meiosis in male Drosophila

Meiosis entails sorting and separating both homologous and sister chromatids. The mechanisms for connecting sister chromatids and homologs during meiosis are highly conserved and include specialized forms of the cohesin complex and a tightly regulated homolog synapsis/recombination pathway designed...

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Detalles Bibliográficos
Autores principales: McKee, Bruce D., Yan, Rihui, Tsai, Jui-He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469440/
https://www.ncbi.nlm.nih.gov/pubmed/23087836
http://dx.doi.org/10.4161/spmg.21800
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author McKee, Bruce D.
Yan, Rihui
Tsai, Jui-He
author_facet McKee, Bruce D.
Yan, Rihui
Tsai, Jui-He
author_sort McKee, Bruce D.
collection PubMed
description Meiosis entails sorting and separating both homologous and sister chromatids. The mechanisms for connecting sister chromatids and homologs during meiosis are highly conserved and include specialized forms of the cohesin complex and a tightly regulated homolog synapsis/recombination pathway designed to yield regular crossovers between homologous chromatids. Drosophila male meiosis is of special interest because it dispenses with large segments of the standard meiotic script, particularly recombination, synapsis and the associated structures. Instead, Drosophila relies on a unique protein complex composed of at least two novel proteins, SNM and MNM, to provide stable connections between homologs during meiosis I. Sister chromatid cohesion in Drosophila is mediated by cohesins, ring-shaped complexes that entrap sister chromatids. However, unlike other eukaryotes Drosophila does not rely on the highly conserved Rec8 cohesin in meiosis, but instead utilizes two novel cohesion proteins, ORD and SOLO, which interact with the SMC1/3 cohesin components in providing meiotic cohesion.
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spelling pubmed-34694402012-10-19 Meiosis in male Drosophila McKee, Bruce D. Yan, Rihui Tsai, Jui-He Spermatogenesis Review Meiosis entails sorting and separating both homologous and sister chromatids. The mechanisms for connecting sister chromatids and homologs during meiosis are highly conserved and include specialized forms of the cohesin complex and a tightly regulated homolog synapsis/recombination pathway designed to yield regular crossovers between homologous chromatids. Drosophila male meiosis is of special interest because it dispenses with large segments of the standard meiotic script, particularly recombination, synapsis and the associated structures. Instead, Drosophila relies on a unique protein complex composed of at least two novel proteins, SNM and MNM, to provide stable connections between homologs during meiosis I. Sister chromatid cohesion in Drosophila is mediated by cohesins, ring-shaped complexes that entrap sister chromatids. However, unlike other eukaryotes Drosophila does not rely on the highly conserved Rec8 cohesin in meiosis, but instead utilizes two novel cohesion proteins, ORD and SOLO, which interact with the SMC1/3 cohesin components in providing meiotic cohesion. Landes Bioscience 2012-07-01 /pmc/articles/PMC3469440/ /pubmed/23087836 http://dx.doi.org/10.4161/spmg.21800 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
McKee, Bruce D.
Yan, Rihui
Tsai, Jui-He
Meiosis in male Drosophila
title Meiosis in male Drosophila
title_full Meiosis in male Drosophila
title_fullStr Meiosis in male Drosophila
title_full_unstemmed Meiosis in male Drosophila
title_short Meiosis in male Drosophila
title_sort meiosis in male drosophila
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469440/
https://www.ncbi.nlm.nih.gov/pubmed/23087836
http://dx.doi.org/10.4161/spmg.21800
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