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Ex Vivo Effect of Varespladib on Secretory Phospholipase A2 Alveolar Activity in Infants with ARDS

BACKGROUND: Secretory phospholipase A2 (sPLA2) plays a pivotal role in acute respiratory distress syndrome (ARDS). This enzyme seems an interesting target to reduce surfactant catabolism and lung tissue inflammation. Varespladib is a specifically designed indolic sPLA2 inhibitor, which has shown pro...

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Detalles Bibliográficos
Autores principales:	De Luca, Daniele, Minucci, Angelo, Piastra, Marco, Cogo, Paola E., Vendittelli, Francesca, Marzano, Laura, Gentile, Leonarda, Giardina, Bruno, Conti, Giorgio, Capoluongo, Ettore D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469496/ https://www.ncbi.nlm.nih.gov/pubmed/23071714 http://dx.doi.org/10.1371/journal.pone.0047066

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