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Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

Apurinic/apyrimidinic endonuclease 1 (APE1) is the main abasic endonuclease in the base excision repair (BER) pathway of DNA lesions caused by oxidation/alkylation in mammalian cells; within nucleoli it interacts with nucleophosmin and rRNA through N-terminal Lys residues, some of which (K(27)/K(31)...

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Detalles Bibliográficos
Autores principales:	Lirussi, Lisa, Antoniali, Giulia, Vascotto, Carlo, D'Ambrosio, Chiara, Poletto, Mattia, Romanello, Milena, Marasco, Daniela, Leone, Marilisa, Quadrifoglio, Franco, Bhakat, Kishor K., Scaloni, Andrea, Tell, Gianluca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469522/ https://www.ncbi.nlm.nih.gov/pubmed/22918947 http://dx.doi.org/10.1091/mbc.E12-04-0299

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