Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes

Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse – a model for human type 1 diabetes (T1D). The molecular events that lead to insulitis and initiate autoimmune diabetes are poorly understood. Since TID is caused by numerous genes, we hypothesized t...

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Detalles Bibliográficos
Autores principales: Wu, Jian, Kakoola, Dorothy N., Lenchik, Nataliya I., Desiderio, Dominic M., Marshall, Dana R., Gerling, Ivan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469658/
https://www.ncbi.nlm.nih.gov/pubmed/23071669
http://dx.doi.org/10.1371/journal.pone.0046941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469658/
https://www.ncbi.nlm.nih.gov/pubmed/23071669
http://dx.doi.org/10.1371/journal.pone.0046941

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