Cargando…

Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes

Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse – a model for human type 1 diabetes (T1D). The molecular events that lead to insulitis and initiate autoimmune diabetes are poorly understood. Since TID is caused by numerous genes, we hypothesized t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Jian, Kakoola, Dorothy N., Lenchik, Nataliya I., Desiderio, Dominic M., Marshall, Dana R., Gerling, Ivan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469658/ https://www.ncbi.nlm.nih.gov/pubmed/23071669 http://dx.doi.org/10.1371/journal.pone.0046941

Ejemplares similares

Transcriptional profiling of CD4 T-lymphocytes reveals abnormal gene expression in young prediabetic NOD mice
por: Kakoola, Dorothy N, et al.
Publicado: (2009)

Molecular pathway alterations in CD4 T-cells of nonobese diabetic (NOD) mice in the preinsulitis phase of autoimmune diabetes
por: Kakoola, Dorothy N., et al.
Publicado: (2014)

Analysis of the transcriptome of CD4 T-Lymphocytes from young Non-Obese Diabetic (NOD) mice suggests a key role for cytokines and apoptosis
por: Kakoola, Dorothy N, et al.
Publicado: (2008)

Differences in gene expression profiles between individual islets from case #6213
por: Lenchik, Nataliya I, et al.
Publicado: (2014)

Approaches to reduce false positives and false negatives in the analysis of microarray data: applications in type 1 diabetes research
por: Wu, Jian, et al.
Publicado: (2008)

Prevention of Autoimmune Diabetes and Induction of β-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy
por: Faleo, Gaetano, et al.
Publicado: (2012)

The NOD Mouse Beyond Autoimmune Diabetes
por: Aubin, Anne-Marie, et al.
Publicado: (2022)

Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes
por: Apaolaza, Paola S., et al.
Publicado: (2021)

Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics
por: Kim, Tae Kang, et al.
Publicado: (2020)

Prevention of Autoimmune Diabetes in NOD Mice by Dimethyl Fumarate
por: Li, Shiri, et al.
Publicado: (2021)

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice
Publicado: (1989)

NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice
por: Beilke, Joshua N., et al.
Publicado: (2012)

Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice
por: Alkan, Manal, et al.
Publicado: (2015)

Inhibition of Autoimmune Diabetes in NOD Mice by miRNA Therapy
por: Wang, Duncheng, et al.
Publicado: (2015)

The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse
por: Borg, Danielle J., et al.
Publicado: (2017)

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice
por: Jhala, Gaurang, et al.
Publicado: (2021)

Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice
por: Sato, Mami, et al.
Publicado: (2021)

The effect of spermidine on autoimmunity and beta cell function in NOD mice
por: Karacay, Ceren, et al.
Publicado: (2022)

Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results From the DiViD Study
por: Krogvold, Lars, et al.
Publicado: (2022)

Induction of HIV mucosal immunity at distal sites after encapsulation of NOD1 and NOD2 ligands in biodegradable nanocarriers
por: Pavot, V, et al.
Publicado: (2012)

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
por: Emamaullee, Juliet A., et al.
Publicado: (2009)

Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice
por: Hillhouse, Erin E., et al.
Publicado: (2013)

TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice
por: Cao, Hui, et al.
Publicado: (2015)

Effect of Arginase-1 Inhibition on the Incidence of Autoimmune Diabetes in NOD Mice
por: Hernandez, Luis F, et al.
Publicado: (2018)

High‐fat diet prevents the development of autoimmune diabetes in NOD mice
por: Clark, Amy L., et al.
Publicado: (2021)

WDFY4 deficiency in NOD mice ameliorates autoimmune diabetes and insulitis
por: Ferris, Stephen T., et al.
Publicado: (2023)

MIF inhibition interferes with the inflammatory and T cell-stimulatory capacity of NOD macrophages and delays autoimmune diabetes onset
por: Korf, Hannelie, et al.
Publicado: (2017)

Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes
por: Leung, Sherman S., et al.
Publicado: (2023)

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity
Publicado: (1996)

NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer
por: Dooley, James, et al.
Publicado: (2017)

Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice
por: Xiao, Ling, et al.
Publicado: (2018)

Autoimmune encephalomyelitis in NOD mice is not initially a progressive multiple sclerosis model
por: Baker, David, et al.
Publicado: (2019)

Toll-like receptor 4 inhibition prevents autoimmune diabetes in NOD mice
por: Alibashe-Ahmed, Mohamed, et al.
Publicado: (2019)

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes
Publicado: (1992)

Phenotyping of Nod1/2 double deficient mice and characterization of Nod1/2 in systemic inflammation and associated renal disease
por: Stroo, Ingrid, et al.
Publicado: (2012)

Development of Spontaneous Autoimmune Peripheral Polyneuropathy in B7-2–Deficient Nod Mice
por: Salomon, Benoît, et al.
Publicado: (2001)

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
por: Vergani, Andrea, et al.
Publicado: (2010)

Targeting B-cells Mitigates Autoimmune Diabetes in NOD Mice: What Is Plan B?
por: Smith, Susan H., et al.
Publicado: (2009)

The Dual Role of Scavenger Receptor Class A in Development of Diabetes in Autoimmune NOD Mice
por: Shimizu, Mami, et al.
Publicado: (2014)

Impact of T-cell-specific Smad4 deficiency on the development of autoimmune diabetes in NOD mice
por: Kim, Donghee, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_le7o1vn16g2pm2somds5hnk86r