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Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia

The balance between excitation and inhibition is considered to be of significant importance for neural computation and cognitive function. Excitatory and inhibitory functional connectivity in intact cortical neuronal networks in wakefulness and graded levels of anesthesia has not been systematically...

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Autores principales: Vizuete, Jeannette A., Pillay, Siveshigan, Diba, Kamran, Ropella, Kristina M., Hudetz, Anthony G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469825/
https://www.ncbi.nlm.nih.gov/pubmed/23091451
http://dx.doi.org/10.3389/fnint.2012.00090
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author Vizuete, Jeannette A.
Pillay, Siveshigan
Diba, Kamran
Ropella, Kristina M.
Hudetz, Anthony G.
author_facet Vizuete, Jeannette A.
Pillay, Siveshigan
Diba, Kamran
Ropella, Kristina M.
Hudetz, Anthony G.
author_sort Vizuete, Jeannette A.
collection PubMed
description The balance between excitation and inhibition is considered to be of significant importance for neural computation and cognitive function. Excitatory and inhibitory functional connectivity in intact cortical neuronal networks in wakefulness and graded levels of anesthesia has not been systematically investigated. We compared monosynaptic excitatory and inhibitory spike transmission probabilities using pairwise cross-correlogram (CCG) analysis. Spikes were measured at 64 sites in the visual cortex of rats with chronically implanted microelectrode arrays during wakefulness and three levels of anesthesia produced by desflurane. Anesthesia decreased the number of active units, the number of functional connections, and the strength of excitatory connections. Connection probability (number of connections per number of active unit pairs) was unaffected until the deepest anesthesia level, at which a significant increase in the excitatory to inhibitory ratio of connection probabilities was observed. The results suggest that the excitatory–inhibitory balance is altered at an anesthetic depth associated with unconsciousness.
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spelling pubmed-34698252012-10-22 Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia Vizuete, Jeannette A. Pillay, Siveshigan Diba, Kamran Ropella, Kristina M. Hudetz, Anthony G. Front Integr Neurosci Neuroscience The balance between excitation and inhibition is considered to be of significant importance for neural computation and cognitive function. Excitatory and inhibitory functional connectivity in intact cortical neuronal networks in wakefulness and graded levels of anesthesia has not been systematically investigated. We compared monosynaptic excitatory and inhibitory spike transmission probabilities using pairwise cross-correlogram (CCG) analysis. Spikes were measured at 64 sites in the visual cortex of rats with chronically implanted microelectrode arrays during wakefulness and three levels of anesthesia produced by desflurane. Anesthesia decreased the number of active units, the number of functional connections, and the strength of excitatory connections. Connection probability (number of connections per number of active unit pairs) was unaffected until the deepest anesthesia level, at which a significant increase in the excitatory to inhibitory ratio of connection probabilities was observed. The results suggest that the excitatory–inhibitory balance is altered at an anesthetic depth associated with unconsciousness. Frontiers Media S.A. 2012-10-12 /pmc/articles/PMC3469825/ /pubmed/23091451 http://dx.doi.org/10.3389/fnint.2012.00090 Text en Copyright © 2012 Vizuete, Pillay, Diba, Ropella and Hudetz. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Vizuete, Jeannette A.
Pillay, Siveshigan
Diba, Kamran
Ropella, Kristina M.
Hudetz, Anthony G.
Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia
title Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia
title_full Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia
title_fullStr Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia
title_full_unstemmed Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia
title_short Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia
title_sort monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469825/
https://www.ncbi.nlm.nih.gov/pubmed/23091451
http://dx.doi.org/10.3389/fnint.2012.00090
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