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Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations
This study used a biomechanical test to evaluate the effects of pentoxifylline administration on the wound healing process of an experimental pressure sore induced in rats. Under general anesthesia and sterile conditions, experimental pressure sores generated by no. 25 Halsted mosquito forceps were...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association for Laboratory Animal Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469850/ https://www.ncbi.nlm.nih.gov/pubmed/23091522 http://dx.doi.org/10.5625/lar.2012.28.3.209 |
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author | Velaei, Kobra Bayat, Mohammad Torkman, Giti Rezaie, Fatemealsadat Amini, Abdollah Noruzian, Mohsen Tavassol, Azaedh Bayat, Mehernoush |
author_facet | Velaei, Kobra Bayat, Mohammad Torkman, Giti Rezaie, Fatemealsadat Amini, Abdollah Noruzian, Mohsen Tavassol, Azaedh Bayat, Mehernoush |
author_sort | Velaei, Kobra |
collection | PubMed |
description | This study used a biomechanical test to evaluate the effects of pentoxifylline administration on the wound healing process of an experimental pressure sore induced in rats. Under general anesthesia and sterile conditions, experimental pressure sores generated by no. 25 Halsted mosquito forceps were inflicted on 12 adult male rats. Pentoxifylline was injected intraperitoneally at a dose of 50 mg/kg daily from the day the pressure sore was generated, for a period of 20 days. At the end of 20 days, rats were sacrificed and skin samples extracted. Samples were biomechanically examined by a material testing instrument for maximum stress (N mm(2)), work up to maximum force (N), and elastic stiffness (N/mm). In the experimental group, maximum stress (2.05±0.15) and work up to maximum force (N/mm) (63.75±4.97) were significantly higher than the control group (1.3±0.27 and 43.3±14.96, P=0.002 and P=0.035, respectively). Pentoxifylline administration significantly accelerated the wound healing process in experimental rats with pressure sores, compared to that of the control group. |
format | Online Article Text |
id | pubmed-3469850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Korean Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34698502012-10-22 Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations Velaei, Kobra Bayat, Mohammad Torkman, Giti Rezaie, Fatemealsadat Amini, Abdollah Noruzian, Mohsen Tavassol, Azaedh Bayat, Mehernoush Lab Anim Res Letter This study used a biomechanical test to evaluate the effects of pentoxifylline administration on the wound healing process of an experimental pressure sore induced in rats. Under general anesthesia and sterile conditions, experimental pressure sores generated by no. 25 Halsted mosquito forceps were inflicted on 12 adult male rats. Pentoxifylline was injected intraperitoneally at a dose of 50 mg/kg daily from the day the pressure sore was generated, for a period of 20 days. At the end of 20 days, rats were sacrificed and skin samples extracted. Samples were biomechanically examined by a material testing instrument for maximum stress (N mm(2)), work up to maximum force (N), and elastic stiffness (N/mm). In the experimental group, maximum stress (2.05±0.15) and work up to maximum force (N/mm) (63.75±4.97) were significantly higher than the control group (1.3±0.27 and 43.3±14.96, P=0.002 and P=0.035, respectively). Pentoxifylline administration significantly accelerated the wound healing process in experimental rats with pressure sores, compared to that of the control group. Korean Association for Laboratory Animal Science 2012-09 2012-09-26 /pmc/articles/PMC3469850/ /pubmed/23091522 http://dx.doi.org/10.5625/lar.2012.28.3.209 Text en Copyright © 2012 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Letter Velaei, Kobra Bayat, Mohammad Torkman, Giti Rezaie, Fatemealsadat Amini, Abdollah Noruzian, Mohsen Tavassol, Azaedh Bayat, Mehernoush Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations |
title | Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations |
title_full | Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations |
title_fullStr | Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations |
title_full_unstemmed | Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations |
title_short | Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations |
title_sort | evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations |
topic | Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469850/ https://www.ncbi.nlm.nih.gov/pubmed/23091522 http://dx.doi.org/10.5625/lar.2012.28.3.209 |
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