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Effect of anti-tuberculosis therapy on polymorphic drug metabolizing enzyme CYP2C9 using phenytoin as a probe drug

OBJECTIVES: Patients on anti-tuberculosis therapy (ATT) are more prone to drug interactions in the presence of coexisting illnesses which warrant drug therapy. Rifampicin is a strong CYP enzyme inducer while isoniazid is a potent CYP inhibitor. The objective of the study was to find the net effect o...

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Detalles Bibliográficos
Autores principales:	George, Melvin, Shewade, Deepak Gopal, Kumar, Saka Vinod, Adithan, Chandrasekaran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469952/ https://www.ncbi.nlm.nih.gov/pubmed/23087510 http://dx.doi.org/10.4103/0253-7613.99314

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