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microRNAs, an active and versatile group in cancers
microRNAs (miRNAs) are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469973/ https://www.ncbi.nlm.nih.gov/pubmed/22010574 http://dx.doi.org/10.4248/IJOS11063 |
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author | Liu, Jeffrey Zheng, Min Tang, Ya-ling Liang, Xin-hua Yang, Qin |
author_facet | Liu, Jeffrey Zheng, Min Tang, Ya-ling Liang, Xin-hua Yang, Qin |
author_sort | Liu, Jeffrey |
collection | PubMed |
description | microRNAs (miRNAs) are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development. miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflammation, anti-cancer drug resistance, and regulation of cancer stem cells. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers. |
format | Online Article Text |
id | pubmed-3469973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-34699732012-10-16 microRNAs, an active and versatile group in cancers Liu, Jeffrey Zheng, Min Tang, Ya-ling Liang, Xin-hua Yang, Qin Int J Oral Sci Review microRNAs (miRNAs) are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development. miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflammation, anti-cancer drug resistance, and regulation of cancer stem cells. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers. Nature Publishing Group 2011-10 /pmc/articles/PMC3469973/ /pubmed/22010574 http://dx.doi.org/10.4248/IJOS11063 Text en Copyright © 2011 West China School of Stomatology http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Review Liu, Jeffrey Zheng, Min Tang, Ya-ling Liang, Xin-hua Yang, Qin microRNAs, an active and versatile group in cancers |
title | microRNAs, an active and versatile group in cancers |
title_full | microRNAs, an active and versatile group in cancers |
title_fullStr | microRNAs, an active and versatile group in cancers |
title_full_unstemmed | microRNAs, an active and versatile group in cancers |
title_short | microRNAs, an active and versatile group in cancers |
title_sort | micrornas, an active and versatile group in cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469973/ https://www.ncbi.nlm.nih.gov/pubmed/22010574 http://dx.doi.org/10.4248/IJOS11063 |
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