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DNA repair and synthetic lethality

Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thu...

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Detalles Bibliográficos
Autores principales:	Guo, Gong-she, Zhang, Feng-mei, Gao, Rui-jie, Delsite, Robert, Feng, Zhi-hui, Powell, Simon N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469974/ https://www.ncbi.nlm.nih.gov/pubmed/22010575 http://dx.doi.org/10.4248/IJOS11064

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