E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability

Cellular senescence is an irreversible cell cycle arrest triggered by the activation of oncogenes or mitogenic signaling as well as the enforced expression of tumor suppressors such as p53, p16(INK4A) and promyelocytic leukemia protein (PML) in normal cells. E2F-binding protein 1 (E2FBP1), a transcr...

Descripción completa

Detalles Bibliográficos
Autores principales: Fukuyo, Yayoi, Takahashi, Akiko, Hara, Eiji, Horikoshi, Nobuo, Pandita, Tej K, Nakajima, Takuma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469977/
https://www.ncbi.nlm.nih.gov/pubmed/22010578
http://dx.doi.org/10.4248/IJOS11071

Ejemplares similares

Ejemplares similares