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Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study
Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogene...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469979/ https://www.ncbi.nlm.nih.gov/pubmed/22010580 http://dx.doi.org/10.4248/IJOS11077 |
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author | Shivamallappa, Shivakumar Madappa Venkatraman, Narayan Tondikulam Shreedhar, Balasundari Mohanty, Leeky Shenoy, Sadhana |
author_facet | Shivamallappa, Shivakumar Madappa Venkatraman, Narayan Tondikulam Shreedhar, Balasundari Mohanty, Leeky Shenoy, Sadhana |
author_sort | Shivamallappa, Shivakumar Madappa |
collection | PubMed |
description | Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogenesis in OSCC development and metastasis is evaluated in this study. This retrospective study of 50 samples consisted of 9 normal buccal mucosa, 22 leukoplakias, and 19 OSCC. Polyclonal antibodies to von-Willebrand factor were used to highlight the microvessels. Images were captured and morphometric image analysis was done for microvessel density (MVD), area, and perimeter. Highest, as well as mean values of these three parameters were compared. MVD and perimeter, but not area, are significantly different between normal mucosa and OSCC, and leukoplakia and OSCC. There were no differences between normal mucosa and leukoplakia. MVD, area, and perimeter were not significantly different between the OSCC with and without lymph node metastasis. The highest and mean values of MVD are significantly correlated. In the development of OSCC, angiogenic phenotypic change occurs in carcinomas rather than in the pre-cancerous stage, and quantification of angiogenesis in OSCC does not predict the risk of lymph node metastasis. |
format | Online Article Text |
id | pubmed-3469979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-34699792012-10-16 Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study Shivamallappa, Shivakumar Madappa Venkatraman, Narayan Tondikulam Shreedhar, Balasundari Mohanty, Leeky Shenoy, Sadhana Int J Oral Sci Original Article Although a few studies have shown that vascularity is increased from normal mucosa to dysplasia to carcinoma suggesting that disease progression in the oral mucosa is accompanied by angiogenesis. The role in lymph node metastasis in oral squamous cell carcinoma (OSCC) is equivocal. Role of angiogenesis in OSCC development and metastasis is evaluated in this study. This retrospective study of 50 samples consisted of 9 normal buccal mucosa, 22 leukoplakias, and 19 OSCC. Polyclonal antibodies to von-Willebrand factor were used to highlight the microvessels. Images were captured and morphometric image analysis was done for microvessel density (MVD), area, and perimeter. Highest, as well as mean values of these three parameters were compared. MVD and perimeter, but not area, are significantly different between normal mucosa and OSCC, and leukoplakia and OSCC. There were no differences between normal mucosa and leukoplakia. MVD, area, and perimeter were not significantly different between the OSCC with and without lymph node metastasis. The highest and mean values of MVD are significantly correlated. In the development of OSCC, angiogenic phenotypic change occurs in carcinomas rather than in the pre-cancerous stage, and quantification of angiogenesis in OSCC does not predict the risk of lymph node metastasis. Nature Publishing Group 2011-10 /pmc/articles/PMC3469979/ /pubmed/22010580 http://dx.doi.org/10.4248/IJOS11077 Text en Copyright © 2011 West China School of Stomatology http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Original Article Shivamallappa, Shivakumar Madappa Venkatraman, Narayan Tondikulam Shreedhar, Balasundari Mohanty, Leeky Shenoy, Sadhana Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study |
title | Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study |
title_full | Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study |
title_fullStr | Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study |
title_full_unstemmed | Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study |
title_short | Role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study |
title_sort | role of angiogenesis in oral squamous cell carcinoma development and metastasis: an immunohistochemical study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469979/ https://www.ncbi.nlm.nih.gov/pubmed/22010580 http://dx.doi.org/10.4248/IJOS11077 |
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