Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation

We apply phase-sensitive optical coherence tomography to image multiple nanoparticle species with two excitation wavelengths matched to their distinct absorption peaks. Using different modulation frequencies, multiple species collocated within the sample can be distinguished. In addition, we charact...

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Detalles Bibliográficos
Autores principales: Kim, Sanghoon, Rinehart, Matthew T., Park, Hansang, Zhu, Yizheng, Wax, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Nanotechnology and Plasmonics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470000/
https://www.ncbi.nlm.nih.gov/pubmed/23082297
http://dx.doi.org/10.1364/BOE.3.002579
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author Kim, Sanghoon
Rinehart, Matthew T.
Park, Hansang
Zhu, Yizheng
Wax, Adam
author_facet Kim, Sanghoon
Rinehart, Matthew T.
Park, Hansang
Zhu, Yizheng
Wax, Adam
author_sort Kim, Sanghoon
collection PubMed
description We apply phase-sensitive optical coherence tomography to image multiple nanoparticle species with two excitation wavelengths matched to their distinct absorption peaks. Using different modulation frequencies, multiple species collocated within the sample can be distinguished. In addition, we characterize single-pulse excitation schemes as a method to minimize bulk heating of the sample. We demonstrate this new scheme with B-mode photothermal measurements of tissue phantoms.
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spelling pubmed-34700002012-10-18 Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation Kim, Sanghoon Rinehart, Matthew T. Park, Hansang Zhu, Yizheng Wax, Adam Biomed Opt Express Nanotechnology and Plasmonics We apply phase-sensitive optical coherence tomography to image multiple nanoparticle species with two excitation wavelengths matched to their distinct absorption peaks. Using different modulation frequencies, multiple species collocated within the sample can be distinguished. In addition, we characterize single-pulse excitation schemes as a method to minimize bulk heating of the sample. We demonstrate this new scheme with B-mode photothermal measurements of tissue phantoms. Optical Society of America 2012-09-17 /pmc/articles/PMC3470000/ /pubmed/23082297 http://dx.doi.org/10.1364/BOE.3.002579 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Nanotechnology and Plasmonics
Kim, Sanghoon
Rinehart, Matthew T.
Park, Hansang
Zhu, Yizheng
Wax, Adam
Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation
title Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation
title_full Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation
title_fullStr Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation
title_full_unstemmed Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation
title_short Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation
title_sort phase-sensitive oct imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation
topic Nanotechnology and Plasmonics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470000/
https://www.ncbi.nlm.nih.gov/pubmed/23082297
http://dx.doi.org/10.1364/BOE.3.002579
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