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Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy

The design and testing of a new, fully automated, calibration approach is described. The process was used to calibrate an image-guided diffuse optical spectroscopy system with 16 photomultiplier tubes (PMTs), but can be extended to any large array of optical detectors and associated imaging geometry...

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Autores principales: Mastanduno, Michael A., Jiang, Shudong, DiFlorio-Alexander, Roberta, Pogue, Brian W., Paulsen, Keith D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470001/
https://www.ncbi.nlm.nih.gov/pubmed/23082277
http://dx.doi.org/10.1364/BOE.3.002339
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author Mastanduno, Michael A.
Jiang, Shudong
DiFlorio-Alexander, Roberta
Pogue, Brian W.
Paulsen, Keith D.
author_facet Mastanduno, Michael A.
Jiang, Shudong
DiFlorio-Alexander, Roberta
Pogue, Brian W.
Paulsen, Keith D.
author_sort Mastanduno, Michael A.
collection PubMed
description The design and testing of a new, fully automated, calibration approach is described. The process was used to calibrate an image-guided diffuse optical spectroscopy system with 16 photomultiplier tubes (PMTs), but can be extended to any large array of optical detectors and associated imaging geometry. The design goals were accomplished by developing a routine for robust automated calibration of the multi-detector array within 45 minutes. Our process was able to characterize individual detectors to a median norm of the residuals of 0.03 V for amplitude and 4.4 degrees in phase and achieved less than 5% variation between all the detectors at the 95% confidence interval for equivalent measurements. Repeatability of the calibrated data from the imaging system was found to be within 0.05 V for amplitude and 0.2 degrees for phase, and was used to evaluate tissue-simulating phantoms in two separate imaging geometries. Spectroscopic imaging of total hemoglobin concentration was recovered to within 5% of the true value in both cases. Future work will focus on streamlining the technology for use in a clinical setting with expectations of achieving accurate quantification of suspicious lesions in the breast.
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spelling pubmed-34700012012-10-18 Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy Mastanduno, Michael A. Jiang, Shudong DiFlorio-Alexander, Roberta Pogue, Brian W. Paulsen, Keith D. Biomed Opt Express Calibration, Validation and Phantom Studies The design and testing of a new, fully automated, calibration approach is described. The process was used to calibrate an image-guided diffuse optical spectroscopy system with 16 photomultiplier tubes (PMTs), but can be extended to any large array of optical detectors and associated imaging geometry. The design goals were accomplished by developing a routine for robust automated calibration of the multi-detector array within 45 minutes. Our process was able to characterize individual detectors to a median norm of the residuals of 0.03 V for amplitude and 4.4 degrees in phase and achieved less than 5% variation between all the detectors at the 95% confidence interval for equivalent measurements. Repeatability of the calibrated data from the imaging system was found to be within 0.05 V for amplitude and 0.2 degrees for phase, and was used to evaluate tissue-simulating phantoms in two separate imaging geometries. Spectroscopic imaging of total hemoglobin concentration was recovered to within 5% of the true value in both cases. Future work will focus on streamlining the technology for use in a clinical setting with expectations of achieving accurate quantification of suspicious lesions in the breast. Optical Society of America 2012-08-31 /pmc/articles/PMC3470001/ /pubmed/23082277 http://dx.doi.org/10.1364/BOE.3.002339 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Calibration, Validation and Phantom Studies
Mastanduno, Michael A.
Jiang, Shudong
DiFlorio-Alexander, Roberta
Pogue, Brian W.
Paulsen, Keith D.
Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy
title Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy
title_full Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy
title_fullStr Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy
title_full_unstemmed Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy
title_short Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy
title_sort automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy
topic Calibration, Validation and Phantom Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470001/
https://www.ncbi.nlm.nih.gov/pubmed/23082277
http://dx.doi.org/10.1364/BOE.3.002339
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