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2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1)
In the crystal structure of the title compound, 2C(10)H(7)NO(4)·C(14)H(13)N(3)O(2), the two independent acid molecules are connected through strong O—H⋯N and O—H⋯O hydrogen bonds to the central molecule of the antitubercular drug N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide. Two such...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470249/ https://www.ncbi.nlm.nih.gov/pubmed/23125693 http://dx.doi.org/10.1107/S1600536812038032 |
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author | Novaković, Sladjana B. Bogdanović, Goran A. Mohamed, Shaaban K. Albayati, Mustafa R. Hameed, Ayad S. |
author_facet | Novaković, Sladjana B. Bogdanović, Goran A. Mohamed, Shaaban K. Albayati, Mustafa R. Hameed, Ayad S. |
author_sort | Novaković, Sladjana B. |
collection | PubMed |
description | In the crystal structure of the title compound, 2C(10)H(7)NO(4)·C(14)H(13)N(3)O(2), the two independent acid molecules are connected through strong O—H⋯N and O—H⋯O hydrogen bonds to the central molecule of the antitubercular drug N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide. Two such trimolecular units related by an inversion centre interact through a pair of N—H⋯O hydrogen bonds, forming a 3 + 3 molecular aggregate. The dihedral angle between the aromatic rings of the hydrazone molecule is 1.99 (12)°. The crystal packing features weak C—H⋯O and π–π stacking interactions, with centroid–centroid distances of 3.8460 (19) and 3.8703 (13) Å. |
format | Online Article Text |
id | pubmed-3470249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-34702492012-11-02 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1) Novaković, Sladjana B. Bogdanović, Goran A. Mohamed, Shaaban K. Albayati, Mustafa R. Hameed, Ayad S. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the crystal structure of the title compound, 2C(10)H(7)NO(4)·C(14)H(13)N(3)O(2), the two independent acid molecules are connected through strong O—H⋯N and O—H⋯O hydrogen bonds to the central molecule of the antitubercular drug N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide. Two such trimolecular units related by an inversion centre interact through a pair of N—H⋯O hydrogen bonds, forming a 3 + 3 molecular aggregate. The dihedral angle between the aromatic rings of the hydrazone molecule is 1.99 (12)°. The crystal packing features weak C—H⋯O and π–π stacking interactions, with centroid–centroid distances of 3.8460 (19) and 3.8703 (13) Å. International Union of Crystallography 2012-09-08 /pmc/articles/PMC3470249/ /pubmed/23125693 http://dx.doi.org/10.1107/S1600536812038032 Text en © Novaković et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Novaković, Sladjana B. Bogdanović, Goran A. Mohamed, Shaaban K. Albayati, Mustafa R. Hameed, Ayad S. 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1) |
title | 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1) |
title_full | 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1) |
title_fullStr | 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1) |
title_full_unstemmed | 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1) |
title_short | 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1) |
title_sort | 2-(1,3-dioxoisoindolin-2-yl)acetic acid–n′-[(e)-4-methoxybenzylidene]pyridine-4-carbohydrazide (2/1) |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470249/ https://www.ncbi.nlm.nih.gov/pubmed/23125693 http://dx.doi.org/10.1107/S1600536812038032 |
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