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2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1)

In the crystal structure of the title compound, 2C(10)H(7)NO(4)·C(14)H(13)N(3)O(2), the two independent acid mol­ecules are connected through strong O—H⋯N and O—H⋯O hydrogen bonds to the central mol­ecule of the anti­tubercular drug N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide. Two such...

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Autores principales: Novaković, Sladjana B., Bogdanović, Goran A., Mohamed, Shaaban K., Albayati, Mustafa R., Hameed, Ayad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470249/
https://www.ncbi.nlm.nih.gov/pubmed/23125693
http://dx.doi.org/10.1107/S1600536812038032
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author Novaković, Sladjana B.
Bogdanović, Goran A.
Mohamed, Shaaban K.
Albayati, Mustafa R.
Hameed, Ayad S.
author_facet Novaković, Sladjana B.
Bogdanović, Goran A.
Mohamed, Shaaban K.
Albayati, Mustafa R.
Hameed, Ayad S.
author_sort Novaković, Sladjana B.
collection PubMed
description In the crystal structure of the title compound, 2C(10)H(7)NO(4)·C(14)H(13)N(3)O(2), the two independent acid mol­ecules are connected through strong O—H⋯N and O—H⋯O hydrogen bonds to the central mol­ecule of the anti­tubercular drug N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide. Two such trimolecular units related by an inversion centre inter­act through a pair of N—H⋯O hydrogen bonds, forming a 3 + 3 mol­ecular aggregate. The dihedral angle between the aromatic rings of the hydrazone mol­ecule is 1.99 (12)°. The crystal packing features weak C—H⋯O and π–π stacking inter­actions, with centroid–centroid distances of 3.8460 (19) and 3.8703 (13) Å.
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spelling pubmed-34702492012-11-02 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1) Novaković, Sladjana B. Bogdanović, Goran A. Mohamed, Shaaban K. Albayati, Mustafa R. Hameed, Ayad S. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the crystal structure of the title compound, 2C(10)H(7)NO(4)·C(14)H(13)N(3)O(2), the two independent acid mol­ecules are connected through strong O—H⋯N and O—H⋯O hydrogen bonds to the central mol­ecule of the anti­tubercular drug N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide. Two such trimolecular units related by an inversion centre inter­act through a pair of N—H⋯O hydrogen bonds, forming a 3 + 3 mol­ecular aggregate. The dihedral angle between the aromatic rings of the hydrazone mol­ecule is 1.99 (12)°. The crystal packing features weak C—H⋯O and π–π stacking inter­actions, with centroid–centroid distances of 3.8460 (19) and 3.8703 (13) Å. International Union of Crystallography 2012-09-08 /pmc/articles/PMC3470249/ /pubmed/23125693 http://dx.doi.org/10.1107/S1600536812038032 Text en © Novaković et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Novaković, Sladjana B.
Bogdanović, Goran A.
Mohamed, Shaaban K.
Albayati, Mustafa R.
Hameed, Ayad S.
2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1)
title 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1)
title_full 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1)
title_fullStr 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1)
title_full_unstemmed 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1)
title_short 2-(1,3-Dioxoisoindolin-2-yl)acetic acid–N′-[(E)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1)
title_sort 2-(1,3-dioxoisoindolin-2-yl)acetic acid–n′-[(e)-4-meth­oxy­benzyl­idene]pyridine-4-carbohydrazide (2/1)
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470249/
https://www.ncbi.nlm.nih.gov/pubmed/23125693
http://dx.doi.org/10.1107/S1600536812038032
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