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(8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one
The title compound, C(10)H(11)NO(3), crystallizes with four independent molecules in the asymmetric unit. Their geometries are very similar and corresponding bond distances are almost identical. The central six-membered ring of the indolizine moiety adopts a envelope conformation [the displacement...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470388/ https://www.ncbi.nlm.nih.gov/pubmed/23125801 http://dx.doi.org/10.1107/S1600536812040378 |
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author | Vrábel, Viktor Švorc, Ľubomír Šafář, Peter Sivý, Július Jozefína, Žúžiová |
author_facet | Vrábel, Viktor Švorc, Ľubomír Šafář, Peter Sivý, Július Jozefína, Žúžiová |
author_sort | Vrábel, Viktor |
collection | PubMed |
description | The title compound, C(10)H(11)NO(3), crystallizes with four independent molecules in the asymmetric unit. Their geometries are very similar and corresponding bond distances are almost identical. The central six-membered ring of the indolizine moiety adopts a envelope conformation [the displacement of the flap atom (the C atom opposite the N atom) being 0.539 (2), 0.548 (3), 0.509 (3) and 0.544 (3) Å in the four molecules], while the conformation of the oxopyrrolidine ring is close to that of a flat envelope. The displacements of the non-fused C atom opposite the C=O group of the pyrrolidine ring of the four molecules are 0.366 (3), 0.335 (3), 0.173 (3) and −0.310 (3) Å. In the crystal, O—H⋯O hydrogen bonds link the molecules into chains, which run parallel to the c axis. The absolute configuration was assigned from the synthesis. |
format | Online Article Text |
id | pubmed-3470388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-34703882012-11-02 (8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one Vrábel, Viktor Švorc, Ľubomír Šafář, Peter Sivý, Július Jozefína, Žúžiová Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(10)H(11)NO(3), crystallizes with four independent molecules in the asymmetric unit. Their geometries are very similar and corresponding bond distances are almost identical. The central six-membered ring of the indolizine moiety adopts a envelope conformation [the displacement of the flap atom (the C atom opposite the N atom) being 0.539 (2), 0.548 (3), 0.509 (3) and 0.544 (3) Å in the four molecules], while the conformation of the oxopyrrolidine ring is close to that of a flat envelope. The displacements of the non-fused C atom opposite the C=O group of the pyrrolidine ring of the four molecules are 0.366 (3), 0.335 (3), 0.173 (3) and −0.310 (3) Å. In the crystal, O—H⋯O hydrogen bonds link the molecules into chains, which run parallel to the c axis. The absolute configuration was assigned from the synthesis. International Union of Crystallography 2012-09-29 /pmc/articles/PMC3470388/ /pubmed/23125801 http://dx.doi.org/10.1107/S1600536812040378 Text en © Vrábel et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Vrábel, Viktor Švorc, Ľubomír Šafář, Peter Sivý, Július Jozefína, Žúžiová (8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one |
title | (8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one |
title_full | (8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one |
title_fullStr | (8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one |
title_full_unstemmed | (8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one |
title_short | (8aR,9R)-9-Hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4H)-one |
title_sort | (8ar,9r)-9-hydroxy-7,8,8a,9-tetrahydrofuro[3,2-f]indolizin-6(4h)-one |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470388/ https://www.ncbi.nlm.nih.gov/pubmed/23125801 http://dx.doi.org/10.1107/S1600536812040378 |
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