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New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)

Long-term storage of biological samples from patients has become increasingly important in studies of disease control and treatment. The first nationwide Danish diabetes project, ie, The Danish Center for Strategic Research in Type II Diabetes (DD2), aims to improve treatment and the long-term outco...

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Detalles Bibliográficos
Autores principales: Christensen, Henry, Nielsen, Jens Steen, Sørensen, Karina Meden, Melbye, Mads, Brandslund, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470454/
https://www.ncbi.nlm.nih.gov/pubmed/23071400
http://dx.doi.org/10.2147/CLEP.S33042
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author Christensen, Henry
Nielsen, Jens Steen
Sørensen, Karina Meden
Melbye, Mads
Brandslund, Ivan
author_facet Christensen, Henry
Nielsen, Jens Steen
Sørensen, Karina Meden
Melbye, Mads
Brandslund, Ivan
author_sort Christensen, Henry
collection PubMed
description Long-term storage of biological samples from patients has become increasingly important in studies of disease control and treatment. The first nationwide Danish diabetes project, ie, The Danish Center for Strategic Research in Type II Diabetes (DD2), aims to improve treatment and the long-term outcome of patients with newly diagnosed type 2 diabetes (T2D). The DD2 project includes establishment of a biobank with samples from 50,000 patients with newly diagnosed T2D. This paper describes how blood and urine samples from 10,000 patients per year are collected, handled, and stored. The biobank includes whole blood, DNA, and plasma and urine samples, all frozen at −80°C. Sampling tubes have been standardized and are sent to hospital outpatient clinics and general practitioners where samples are taken, handled, aliquoted, and returned by mail overnight in standardized cryostorage tubes. When received at the biobank, samples are frozen without further treatment. From each patient, 24 cryostorage tubes are stored. Each tube is labeled with a barcode that links the data to other information available in a clinical databank registry. When patients are enrolled in DD2, a questionnaire is filled out and a quality monitoring system ensures that patients, samples, and questionnaires can be linked together at all times. The biobank is located at Vejle Hospital and the Danish National Biobank at Statens Serum Institut. As of the end of March 2012, samples from 1186 patients have been stored, and currently samples from 8–10 patients arrive per day. We have established the first national biobank in Denmark where blood, DNA, and plasma and urine samples from patients with newly diagnosed T2D are systematically collected and stored. This biobank enables sophisticated analysis of genetic variation and response to treatment, as well as disease marker studies that better classify disease status, progression, and complications.
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spelling pubmed-34704542012-10-15 New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2) Christensen, Henry Nielsen, Jens Steen Sørensen, Karina Meden Melbye, Mads Brandslund, Ivan Clin Epidemiol Commentary Long-term storage of biological samples from patients has become increasingly important in studies of disease control and treatment. The first nationwide Danish diabetes project, ie, The Danish Center for Strategic Research in Type II Diabetes (DD2), aims to improve treatment and the long-term outcome of patients with newly diagnosed type 2 diabetes (T2D). The DD2 project includes establishment of a biobank with samples from 50,000 patients with newly diagnosed T2D. This paper describes how blood and urine samples from 10,000 patients per year are collected, handled, and stored. The biobank includes whole blood, DNA, and plasma and urine samples, all frozen at −80°C. Sampling tubes have been standardized and are sent to hospital outpatient clinics and general practitioners where samples are taken, handled, aliquoted, and returned by mail overnight in standardized cryostorage tubes. When received at the biobank, samples are frozen without further treatment. From each patient, 24 cryostorage tubes are stored. Each tube is labeled with a barcode that links the data to other information available in a clinical databank registry. When patients are enrolled in DD2, a questionnaire is filled out and a quality monitoring system ensures that patients, samples, and questionnaires can be linked together at all times. The biobank is located at Vejle Hospital and the Danish National Biobank at Statens Serum Institut. As of the end of March 2012, samples from 1186 patients have been stored, and currently samples from 8–10 patients arrive per day. We have established the first national biobank in Denmark where blood, DNA, and plasma and urine samples from patients with newly diagnosed T2D are systematically collected and stored. This biobank enables sophisticated analysis of genetic variation and response to treatment, as well as disease marker studies that better classify disease status, progression, and complications. Dove Medical Press 2012-09-21 /pmc/articles/PMC3470454/ /pubmed/23071400 http://dx.doi.org/10.2147/CLEP.S33042 Text en © 2012 Christensen et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Commentary
Christensen, Henry
Nielsen, Jens Steen
Sørensen, Karina Meden
Melbye, Mads
Brandslund, Ivan
New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)
title New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)
title_full New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)
title_fullStr New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)
title_full_unstemmed New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)
title_short New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)
title_sort new national biobank of the danish center for strategic research on type 2 diabetes (dd2)
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470454/
https://www.ncbi.nlm.nih.gov/pubmed/23071400
http://dx.doi.org/10.2147/CLEP.S33042
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