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Phylogenetic and Evolutionary History of Influenza B Viruses, which Caused a Large Epidemic in 2011–2012, Taiwan

The annual recurrence of the influenza epidemic is considered to be primarily associated with immune escape due to changes to the virus. In 2011–2012, the influenza B epidemic in Taiwan was unusually large, and influenza B was predominant for a long time. To investigate the genetic dynamics of influ...

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Autores principales: Yang, Ji-Rong, Huang, Yuan-Pin, Chang, Feng-Yee, Hsu, Li-Ching, Lin, Yu-Cheng, Huang, Hsiang-Yi, Wu, Fu-Ting, Wu, Ho-Sheng, Liu, Ming-Tsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470568/
https://www.ncbi.nlm.nih.gov/pubmed/23071751
http://dx.doi.org/10.1371/journal.pone.0047179
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author Yang, Ji-Rong
Huang, Yuan-Pin
Chang, Feng-Yee
Hsu, Li-Ching
Lin, Yu-Cheng
Huang, Hsiang-Yi
Wu, Fu-Ting
Wu, Ho-Sheng
Liu, Ming-Tsan
author_facet Yang, Ji-Rong
Huang, Yuan-Pin
Chang, Feng-Yee
Hsu, Li-Ching
Lin, Yu-Cheng
Huang, Hsiang-Yi
Wu, Fu-Ting
Wu, Ho-Sheng
Liu, Ming-Tsan
author_sort Yang, Ji-Rong
collection PubMed
description The annual recurrence of the influenza epidemic is considered to be primarily associated with immune escape due to changes to the virus. In 2011–2012, the influenza B epidemic in Taiwan was unusually large, and influenza B was predominant for a long time. To investigate the genetic dynamics of influenza B viruses during the 2011–2012 epidemic, we analyzed the sequences of 4,386 influenza B viruses collected in Taiwan from 2004 to 2012. The data provided detailed insight into the flux patterns of multiple genotypes. We found that a re-emergent TW08-I virus, which was the major genotype and had co-circulated with the two others, TW08-II and TW08-III, from 2007 to 2009 in Taiwan, successively overtook TW08-II in March and then underwent a lineage switch in July 2011. This lineage switch was followed by the large epidemic in Taiwan. The whole-genome compositions and phylogenetic relationships of the representative viruses of various genotypes were compared to determine the viral evolutionary histories. We demonstrated that the large influenza B epidemic of 2011–2012 was caused by Yamagata lineage TW08-I viruses that were derived from TW04-II viruses in 2004–2005 through genetic drifts without detectable reassortments. The TW08-I viruses isolated in both 2011–2012 and 2007–2009 were antigenically similar, indicating that an influenza B virus have persisted for 5 years in antigenic stasis before causing a large epidemic. The results suggest that in addition to the emergence of new variants with mutations or reassortments, other factors, including the interference of multi-types or lineages of influenza viruses and the accumulation of susceptible hosts, can also affect the scale and time of an influenza B epidemic.
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spelling pubmed-34705682012-10-15 Phylogenetic and Evolutionary History of Influenza B Viruses, which Caused a Large Epidemic in 2011–2012, Taiwan Yang, Ji-Rong Huang, Yuan-Pin Chang, Feng-Yee Hsu, Li-Ching Lin, Yu-Cheng Huang, Hsiang-Yi Wu, Fu-Ting Wu, Ho-Sheng Liu, Ming-Tsan PLoS One Research Article The annual recurrence of the influenza epidemic is considered to be primarily associated with immune escape due to changes to the virus. In 2011–2012, the influenza B epidemic in Taiwan was unusually large, and influenza B was predominant for a long time. To investigate the genetic dynamics of influenza B viruses during the 2011–2012 epidemic, we analyzed the sequences of 4,386 influenza B viruses collected in Taiwan from 2004 to 2012. The data provided detailed insight into the flux patterns of multiple genotypes. We found that a re-emergent TW08-I virus, which was the major genotype and had co-circulated with the two others, TW08-II and TW08-III, from 2007 to 2009 in Taiwan, successively overtook TW08-II in March and then underwent a lineage switch in July 2011. This lineage switch was followed by the large epidemic in Taiwan. The whole-genome compositions and phylogenetic relationships of the representative viruses of various genotypes were compared to determine the viral evolutionary histories. We demonstrated that the large influenza B epidemic of 2011–2012 was caused by Yamagata lineage TW08-I viruses that were derived from TW04-II viruses in 2004–2005 through genetic drifts without detectable reassortments. The TW08-I viruses isolated in both 2011–2012 and 2007–2009 were antigenically similar, indicating that an influenza B virus have persisted for 5 years in antigenic stasis before causing a large epidemic. The results suggest that in addition to the emergence of new variants with mutations or reassortments, other factors, including the interference of multi-types or lineages of influenza viruses and the accumulation of susceptible hosts, can also affect the scale and time of an influenza B epidemic. Public Library of Science 2012-10-12 /pmc/articles/PMC3470568/ /pubmed/23071751 http://dx.doi.org/10.1371/journal.pone.0047179 Text en © 2012 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yang, Ji-Rong
Huang, Yuan-Pin
Chang, Feng-Yee
Hsu, Li-Ching
Lin, Yu-Cheng
Huang, Hsiang-Yi
Wu, Fu-Ting
Wu, Ho-Sheng
Liu, Ming-Tsan
Phylogenetic and Evolutionary History of Influenza B Viruses, which Caused a Large Epidemic in 2011–2012, Taiwan
title Phylogenetic and Evolutionary History of Influenza B Viruses, which Caused a Large Epidemic in 2011–2012, Taiwan
title_full Phylogenetic and Evolutionary History of Influenza B Viruses, which Caused a Large Epidemic in 2011–2012, Taiwan
title_fullStr Phylogenetic and Evolutionary History of Influenza B Viruses, which Caused a Large Epidemic in 2011–2012, Taiwan
title_full_unstemmed Phylogenetic and Evolutionary History of Influenza B Viruses, which Caused a Large Epidemic in 2011–2012, Taiwan
title_short Phylogenetic and Evolutionary History of Influenza B Viruses, which Caused a Large Epidemic in 2011–2012, Taiwan
title_sort phylogenetic and evolutionary history of influenza b viruses, which caused a large epidemic in 2011–2012, taiwan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470568/
https://www.ncbi.nlm.nih.gov/pubmed/23071751
http://dx.doi.org/10.1371/journal.pone.0047179
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