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Human JCV Infections as a Bio-Anthropological Marker of the Formation of Brazilian Amazonian Populations

JC polyomavirus (JCV) is a member of the Polyomaviridae family. It presents a tropism to kidney cells, and the infection occurs in a variety of human population groups of different ethnic background. The present study investigated the prevalence of JCV infection among human populations from the Braz...

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Autores principales: Cayres-Vallinoto, Izaura M. V., Vallinoto, Antonio C. R., Azevedo, Vânia N., Machado, Luis Fernando Almeida, Ishak, Marluísa de Oliveira Guimarães, Ishak, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470572/
https://www.ncbi.nlm.nih.gov/pubmed/23071582
http://dx.doi.org/10.1371/journal.pone.0046523
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author Cayres-Vallinoto, Izaura M. V.
Vallinoto, Antonio C. R.
Azevedo, Vânia N.
Machado, Luis Fernando Almeida
Ishak, Marluísa de Oliveira Guimarães
Ishak, Ricardo
author_facet Cayres-Vallinoto, Izaura M. V.
Vallinoto, Antonio C. R.
Azevedo, Vânia N.
Machado, Luis Fernando Almeida
Ishak, Marluísa de Oliveira Guimarães
Ishak, Ricardo
author_sort Cayres-Vallinoto, Izaura M. V.
collection PubMed
description JC polyomavirus (JCV) is a member of the Polyomaviridae family. It presents a tropism to kidney cells, and the infection occurs in a variety of human population groups of different ethnic background. The present study investigated the prevalence of JCV infection among human populations from the Brazilian Amazon region, and describes the molecular and phylogenetic features of the virus. Urine samples from two urban groups of Belém (healthy subjects), one Brazilian Afro-descendant “quilombo” from the Rio Trombetas region, and native Indians from the Wai-Wai, Urubu-Kaapor, Tembé, Assurini, Arara do Laranjal, Aukre, Parakanã, Surui and Munduruku villages were investigated for the presence of the virus by amplifying VP1 (230 bp) and IG (610 bp) regions using a polymerase chain reaction. Nucleotide sequences (440 nucleotides, nt) from 48 samples were submitted to phylogenetic analysis. The results confirmed the occurrence of types A (subtype EU), B (subtypes Af-2, African and MY, Asiatic) and C (subtype Af-1) among healthy subjects; type B, subtypes Af-2 and MY, among the Afro-Brazilians; and type B, subtype MY, within the Surui Indians. An unexpected result was the detection of another polyomavirus, the BKV, among Afro-descendants. The present study shows, for the first time, the occurrence of JC and BK polyomaviruses infecting humans from the Brazilian Amazon region. The results show a large genetic variability of strains circulating in the region, infecting a large group of individuals. The presence of European, Asiatic and African subtypes associated to the ethnic origin of the population samples investigated herein, highlights the idea that JCV is a fairly good marker for studying the early migration of human populations, reflecting their early and late history. Furthermore, the identification of the specific mutations associated to the virus subtypes, suggests that these mutations have occurred after the entrance of the virus in the Amazon region of Brazil.
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spelling pubmed-34705722012-10-15 Human JCV Infections as a Bio-Anthropological Marker of the Formation of Brazilian Amazonian Populations Cayres-Vallinoto, Izaura M. V. Vallinoto, Antonio C. R. Azevedo, Vânia N. Machado, Luis Fernando Almeida Ishak, Marluísa de Oliveira Guimarães Ishak, Ricardo PLoS One Research Article JC polyomavirus (JCV) is a member of the Polyomaviridae family. It presents a tropism to kidney cells, and the infection occurs in a variety of human population groups of different ethnic background. The present study investigated the prevalence of JCV infection among human populations from the Brazilian Amazon region, and describes the molecular and phylogenetic features of the virus. Urine samples from two urban groups of Belém (healthy subjects), one Brazilian Afro-descendant “quilombo” from the Rio Trombetas region, and native Indians from the Wai-Wai, Urubu-Kaapor, Tembé, Assurini, Arara do Laranjal, Aukre, Parakanã, Surui and Munduruku villages were investigated for the presence of the virus by amplifying VP1 (230 bp) and IG (610 bp) regions using a polymerase chain reaction. Nucleotide sequences (440 nucleotides, nt) from 48 samples were submitted to phylogenetic analysis. The results confirmed the occurrence of types A (subtype EU), B (subtypes Af-2, African and MY, Asiatic) and C (subtype Af-1) among healthy subjects; type B, subtypes Af-2 and MY, among the Afro-Brazilians; and type B, subtype MY, within the Surui Indians. An unexpected result was the detection of another polyomavirus, the BKV, among Afro-descendants. The present study shows, for the first time, the occurrence of JC and BK polyomaviruses infecting humans from the Brazilian Amazon region. The results show a large genetic variability of strains circulating in the region, infecting a large group of individuals. The presence of European, Asiatic and African subtypes associated to the ethnic origin of the population samples investigated herein, highlights the idea that JCV is a fairly good marker for studying the early migration of human populations, reflecting their early and late history. Furthermore, the identification of the specific mutations associated to the virus subtypes, suggests that these mutations have occurred after the entrance of the virus in the Amazon region of Brazil. Public Library of Science 2012-10-12 /pmc/articles/PMC3470572/ /pubmed/23071582 http://dx.doi.org/10.1371/journal.pone.0046523 Text en © 2012 Cayres-Vallinoto et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cayres-Vallinoto, Izaura M. V.
Vallinoto, Antonio C. R.
Azevedo, Vânia N.
Machado, Luis Fernando Almeida
Ishak, Marluísa de Oliveira Guimarães
Ishak, Ricardo
Human JCV Infections as a Bio-Anthropological Marker of the Formation of Brazilian Amazonian Populations
title Human JCV Infections as a Bio-Anthropological Marker of the Formation of Brazilian Amazonian Populations
title_full Human JCV Infections as a Bio-Anthropological Marker of the Formation of Brazilian Amazonian Populations
title_fullStr Human JCV Infections as a Bio-Anthropological Marker of the Formation of Brazilian Amazonian Populations
title_full_unstemmed Human JCV Infections as a Bio-Anthropological Marker of the Formation of Brazilian Amazonian Populations
title_short Human JCV Infections as a Bio-Anthropological Marker of the Formation of Brazilian Amazonian Populations
title_sort human jcv infections as a bio-anthropological marker of the formation of brazilian amazonian populations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470572/
https://www.ncbi.nlm.nih.gov/pubmed/23071582
http://dx.doi.org/10.1371/journal.pone.0046523
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