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Renal IL-18 Production Is Macrophage Independent During Obstructive Injury

BACKGROUND: Interleukin 18 (IL-18) is a pro-inflammatory cytokine that mediates fibrotic renal injury during obstruction. Macrophages are a well-known source of IL-18; however, renal tubular epithelial cells are also a potential source of this cytokine. We hypothesized that IL-18 is predominantly a...

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Detalles Bibliográficos
Autores principales:	Franke, Ethan I., Vanderbrink, Brian A., Hile, Karen L., Zhang, Hongji, Cain, Alexandra, Matsui, Futoshi, Meldrum, Kirstan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470595/ https://www.ncbi.nlm.nih.gov/pubmed/23077611 http://dx.doi.org/10.1371/journal.pone.0047417

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