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The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders
Rare disruptions of FOXP2 have been strongly implicated in deficits in language development. Research over the past decade has suggested a role in the formation of underlying neural circuits required for speech. Until recently no evidence existed to suggest that the closely related FOXP1 gene played...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470686/ https://www.ncbi.nlm.nih.gov/pubmed/22736078 http://dx.doi.org/10.1007/s00439-012-1193-z |
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author | Bacon, Claire Rappold, Gudrun A. |
author_facet | Bacon, Claire Rappold, Gudrun A. |
author_sort | Bacon, Claire |
collection | PubMed |
description | Rare disruptions of FOXP2 have been strongly implicated in deficits in language development. Research over the past decade has suggested a role in the formation of underlying neural circuits required for speech. Until recently no evidence existed to suggest that the closely related FOXP1 gene played a role in neurodevelopmental processes. However, in the last few years, novel rare disruptions in FOXP1 have been reported in multiple cases of cognitive dysfunction, including intellectual disability and autism spectrum disorder, together with language impairment. As FOXP1 and FOXP2 form heterodimers for transcriptional regulation, one may assume that they co-operate in common neurodevelopmental pathways through the co-regulation of common targets. Here we compare the phenotypic consequences of FOXP1 and FOXP2 impairment, drawing on well-known studies from the past as well as recent exciting findings and consider what these tell us regarding the functions of these two genes in neural development. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00439-012-1193-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-3470686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-34706862012-10-18 The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders Bacon, Claire Rappold, Gudrun A. Hum Genet Review Paper Rare disruptions of FOXP2 have been strongly implicated in deficits in language development. Research over the past decade has suggested a role in the formation of underlying neural circuits required for speech. Until recently no evidence existed to suggest that the closely related FOXP1 gene played a role in neurodevelopmental processes. However, in the last few years, novel rare disruptions in FOXP1 have been reported in multiple cases of cognitive dysfunction, including intellectual disability and autism spectrum disorder, together with language impairment. As FOXP1 and FOXP2 form heterodimers for transcriptional regulation, one may assume that they co-operate in common neurodevelopmental pathways through the co-regulation of common targets. Here we compare the phenotypic consequences of FOXP1 and FOXP2 impairment, drawing on well-known studies from the past as well as recent exciting findings and consider what these tell us regarding the functions of these two genes in neural development. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00439-012-1193-z) contains supplementary material, which is available to authorized users. Springer-Verlag 2012-06-27 2012 /pmc/articles/PMC3470686/ /pubmed/22736078 http://dx.doi.org/10.1007/s00439-012-1193-z Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Paper Bacon, Claire Rappold, Gudrun A. The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders |
title | The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders |
title_full | The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders |
title_fullStr | The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders |
title_full_unstemmed | The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders |
title_short | The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders |
title_sort | distinct and overlapping phenotypic spectra of foxp1 and foxp2 in cognitive disorders |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470686/ https://www.ncbi.nlm.nih.gov/pubmed/22736078 http://dx.doi.org/10.1007/s00439-012-1193-z |
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