Investigate the Role of Glutathione S Transferase (GST) Polymorphism in Development of Hypertension in UAE Population

BACKGROUND: GST is a family of enzymes that are important in protection of the body against oxidative stress. OBJECTIVES: Investigate the association between GSTT1 and GSTM1 polymorphism and hypertension. MATERIALS AND METHODS: GSTT1 and GSTM1 genotypes were detected by PCR. The fragments were then...

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Detalles Bibliográficos
Autores principales: Hussain, Kosar, Salah, Neveen, Hussain, Sahar, Hussain, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470842/
https://www.ncbi.nlm.nih.gov/pubmed/23105984
Descripción
Sumario:BACKGROUND: GST is a family of enzymes that are important in protection of the body against oxidative stress. OBJECTIVES: Investigate the association between GSTT1 and GSTM1 polymorphism and hypertension. MATERIALS AND METHODS: GSTT1 and GSTM1 genotypes were detected by PCR. The fragments were then analyzed by agarose gel electrophoresis. RESULTS: There is no significant association between GSTT1 & GSTM1 polymorphism and hypertension (OR = 2.4, P > 0.05 and OR = 1.6, P > 0.05) CONCLUSIONS: GSTT1 & GSTM1 polymorphism can be considered a risk factor for hypertension.

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