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Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection
As a leading cause of childhood mortality worldwide, selection pressure by Plasmodium falciparum continues to shape the human genome. Severe disturbances within the microcirculation result from the adhesion of infected erythrocytes to host receptors on monocytes, platelets, and endothelium. In this...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470923/ https://www.ncbi.nlm.nih.gov/pubmed/22909232 http://dx.doi.org/10.1111/bjh.12014 |
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author | Cserti-Gazdewich, Christine M Dhabangi, Aggrey Musoke, Charles Ssewanyana, Isaac Ddungu, Henry Nakiboneka-Ssenabulya, Deborah Nabukeera-Barungi, Nicolette Mpimbaza, Arthur Dzik, Walter H |
author_facet | Cserti-Gazdewich, Christine M Dhabangi, Aggrey Musoke, Charles Ssewanyana, Isaac Ddungu, Henry Nakiboneka-Ssenabulya, Deborah Nabukeera-Barungi, Nicolette Mpimbaza, Arthur Dzik, Walter H |
author_sort | Cserti-Gazdewich, Christine M |
collection | PubMed |
description | As a leading cause of childhood mortality worldwide, selection pressure by Plasmodium falciparum continues to shape the human genome. Severe disturbances within the microcirculation result from the adhesion of infected erythrocytes to host receptors on monocytes, platelets, and endothelium. In this prospective study, we compared expression of all major host cytoadhesion receptors among Ugandan children presenting with uncomplicated malaria (n = 1078) versus children with severe malaria (n = 855), including cerebral malaria (n = 174), severe anaemia (n = 522), and lactic acidosis (n = 154). We report a significant survival advantage attributed to blood group O and increased monocyte expression of CD36 and ICAM1 (CD54). The high case fatality rate syndromes of cerebral malaria and lactic acidosis were associated with high platelet CD36 expression and thrombocytopenia, and severe malaria anaemia was characterized by low ICAM1 expression. In a logistic regression model of disease severity, odds ratios for the mitigating effects of blood group O, CD36, and ICAM1 phenotypes were greater than that of sickle haemoglobin. Host genetic adaptations to Plasmodium falciparum suggest new potential malaria treatment strategies. |
format | Online Article Text |
id | pubmed-3470923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-34709232012-10-18 Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection Cserti-Gazdewich, Christine M Dhabangi, Aggrey Musoke, Charles Ssewanyana, Isaac Ddungu, Henry Nakiboneka-Ssenabulya, Deborah Nabukeera-Barungi, Nicolette Mpimbaza, Arthur Dzik, Walter H Br J Haematol Red Cells and Iron As a leading cause of childhood mortality worldwide, selection pressure by Plasmodium falciparum continues to shape the human genome. Severe disturbances within the microcirculation result from the adhesion of infected erythrocytes to host receptors on monocytes, platelets, and endothelium. In this prospective study, we compared expression of all major host cytoadhesion receptors among Ugandan children presenting with uncomplicated malaria (n = 1078) versus children with severe malaria (n = 855), including cerebral malaria (n = 174), severe anaemia (n = 522), and lactic acidosis (n = 154). We report a significant survival advantage attributed to blood group O and increased monocyte expression of CD36 and ICAM1 (CD54). The high case fatality rate syndromes of cerebral malaria and lactic acidosis were associated with high platelet CD36 expression and thrombocytopenia, and severe malaria anaemia was characterized by low ICAM1 expression. In a logistic regression model of disease severity, odds ratios for the mitigating effects of blood group O, CD36, and ICAM1 phenotypes were greater than that of sickle haemoglobin. Host genetic adaptations to Plasmodium falciparum suggest new potential malaria treatment strategies. Blackwell Publishing Ltd 2012-10 2012-08-22 /pmc/articles/PMC3470923/ /pubmed/22909232 http://dx.doi.org/10.1111/bjh.12014 Text en Copyright © 2012 Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Red Cells and Iron Cserti-Gazdewich, Christine M Dhabangi, Aggrey Musoke, Charles Ssewanyana, Isaac Ddungu, Henry Nakiboneka-Ssenabulya, Deborah Nabukeera-Barungi, Nicolette Mpimbaza, Arthur Dzik, Walter H Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection |
title | Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection |
title_full | Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection |
title_fullStr | Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection |
title_full_unstemmed | Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection |
title_short | Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection |
title_sort | cytoadherence in paediatric malaria: abo blood group, cd36, and icam1 expression and severe plasmodium falciparum infection |
topic | Red Cells and Iron |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470923/ https://www.ncbi.nlm.nih.gov/pubmed/22909232 http://dx.doi.org/10.1111/bjh.12014 |
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