Transcription factors involved in the regulation of natural killer cell development and function: an update

Natural killer (NK) cells belong to the innate immune system and are key effectors in the immune response against cancer and infection. Recent studies have contributed to the knowledge of events controlling NK cell fate. The use of knockout mice has enabled the discovery of key transcription factors...

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Autores principales: Luevano, Martha, Madrigal, Alejandro, Saudemont, Aurore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470934/
https://www.ncbi.nlm.nih.gov/pubmed/23087693
http://dx.doi.org/10.3389/fimmu.2012.00319
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author Luevano, Martha
Madrigal, Alejandro
Saudemont, Aurore
author_facet Luevano, Martha
Madrigal, Alejandro
Saudemont, Aurore
author_sort Luevano, Martha
collection PubMed
description Natural killer (NK) cells belong to the innate immune system and are key effectors in the immune response against cancer and infection. Recent studies have contributed to the knowledge of events controlling NK cell fate. The use of knockout mice has enabled the discovery of key transcription factors (TFs) essential for NK cell development and function. Yet, unwrapping the downstream targets of these TFs and their influence on NK cells remains a challenge. In this review, we discuss the latest TFs described to be involved in the regulation of NK cell development and maturation.
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spelling pubmed-34709342012-10-19 Transcription factors involved in the regulation of natural killer cell development and function: an update Luevano, Martha Madrigal, Alejandro Saudemont, Aurore Front Immunol Immunology Natural killer (NK) cells belong to the innate immune system and are key effectors in the immune response against cancer and infection. Recent studies have contributed to the knowledge of events controlling NK cell fate. The use of knockout mice has enabled the discovery of key transcription factors (TFs) essential for NK cell development and function. Yet, unwrapping the downstream targets of these TFs and their influence on NK cells remains a challenge. In this review, we discuss the latest TFs described to be involved in the regulation of NK cell development and maturation. Frontiers Media S.A. 2012-10-15 /pmc/articles/PMC3470934/ /pubmed/23087693 http://dx.doi.org/10.3389/fimmu.2012.00319 Text en Copyright © Luevano, Madrigal and Saudemont. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Luevano, Martha
Madrigal, Alejandro
Saudemont, Aurore
Transcription factors involved in the regulation of natural killer cell development and function: an update
title Transcription factors involved in the regulation of natural killer cell development and function: an update
title_full Transcription factors involved in the regulation of natural killer cell development and function: an update
title_fullStr Transcription factors involved in the regulation of natural killer cell development and function: an update
title_full_unstemmed Transcription factors involved in the regulation of natural killer cell development and function: an update
title_short Transcription factors involved in the regulation of natural killer cell development and function: an update
title_sort transcription factors involved in the regulation of natural killer cell development and function: an update
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470934/
https://www.ncbi.nlm.nih.gov/pubmed/23087693
http://dx.doi.org/10.3389/fimmu.2012.00319
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