Hypermethylation of the 5′ CpG island of the p14(ARF) flanking exon 1β in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression

BACKGROUND: It has been suggested that inactivation of p14(ARF), a tumor suppressor central to regulating p53 protein stability through interaction with the MDM2 oncoprotein, abrogates p53 activity in human tumors retaining the wild-type TP53 gene. Differences in expression of tumor suppressor genes...

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Detalles Bibliográficos
Autores principales: Nyiraneza, Christine, Sempoux, Christine, Detry, Roger, Kartheuser, Alex, Dahan, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470942/
https://www.ncbi.nlm.nih.gov/pubmed/22703554
http://dx.doi.org/10.1186/1868-7083-4-9

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