Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?

Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has been possible to inhibit viral replic...

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Detalles Bibliográficos
Autores principales: Savarino, Andrea, Garaci, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Viewpoints
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470962/
https://www.ncbi.nlm.nih.gov/pubmed/22978787
http://dx.doi.org/10.1186/1742-4690-9-75
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author Savarino, Andrea
Garaci, Enrico
author_facet Savarino, Andrea
Garaci, Enrico
author_sort Savarino, Andrea
collection PubMed
description Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has been possible to inhibit viral replication to levels below the assay detection limit in the macaque AIDS model. Moreover, different therapeutic regimens applied to the rhesus macaque AIDS model (herein reviewed), including ours, are starting to show the potential to induce, following therapy suspension, conditions reminiscent of a drug-free control of the infection.
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spelling pubmed-34709622012-10-16 Therapeutic imprinting of the immune system: towards a remission of AIDS in primates? Savarino, Andrea Garaci, Enrico Retrovirology Viewpoints Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has been possible to inhibit viral replication to levels below the assay detection limit in the macaque AIDS model. Moreover, different therapeutic regimens applied to the rhesus macaque AIDS model (herein reviewed), including ours, are starting to show the potential to induce, following therapy suspension, conditions reminiscent of a drug-free control of the infection. BioMed Central 2012-09-14 /pmc/articles/PMC3470962/ /pubmed/22978787 http://dx.doi.org/10.1186/1742-4690-9-75 Text en Copyright ©2012 Savarino and Garaci; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Viewpoints
Savarino, Andrea
Garaci, Enrico
Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
title Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
title_full Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
title_fullStr Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
title_full_unstemmed Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
title_short Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
title_sort therapeutic imprinting of the immune system: towards a remission of aids in primates?
topic Viewpoints
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470962/
https://www.ncbi.nlm.nih.gov/pubmed/22978787
http://dx.doi.org/10.1186/1742-4690-9-75
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